SU 1498

SKU
S-2447
  • Formula:C25H30N2O2
  • MW:390.52
  • Appearance:Yellow Powder
  • Purity:98% by TLC
Product Name Qty
SU 1498
1 mg
$62.65
SU 1498
5 mg
$187.95

A potent and selective inhibitor (IC= 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 M), EGFR-kinase (IC100 M)and HER-2 kinase (IC100 M). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.

More Information
Alternate Name/Synonyms
Tyrphostin SU 1498; (E)-N-(3-Phenylpropyl)-cyano-3,5-diisopropyl-4-hydroxycinnamamide
SKU
S-2447
Chemical Name
Tyrphostin SU 1498; (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
Chemical Formula
C25H30N2O2
Molecular Weight
390.52
Appearance
Yellow Powder
Purity
98% by TLC
Solubility
DMSO (~20 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 in tumor growth.
MDL NUMBER
MFCD03453026
CHEMACX
X1276572-1
INCHI
InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
SMILES
CC(C)c1cc(cc(c1O)C(C)C)/C=C(C#N)/C(=O)NCCCc2ccccc2
Handling
Protect from air and light
HandlingProtect from air and light
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