SU11248
341031-54-7
532.6
C22H27FN4O2 • C4H6O5
DMF, DMSO
-20°C
Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an ICof 7 nM, and inhibits receptor phosphorylation in a cellular assay with an ICof 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC= 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an ICvalue consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC= 2 nM).
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
