Swainsonine

SKU
S-3351
  • CAS:72741-87-8
  • Formula:C8H15NO3
  • MW:173.20 Da
  • Appearance:White powder
  • Purity:98%
Product Name Qty
Swainsonine
1 mg
$109.20
Swainsonine
5 mg
$436.80

Swainsonine is known to be produced by fungal symbionts of plants (endophytes), plant pathogens, and insect pathogens. It is an indolizidine alkaloid, a mannofuranose analog, that specifically inhibits a-mannosidase II in the Golgi apparatus, disrupting the endomembrane system of the cell. Swainsonine is under consideration as a component of chemotherapeutic treatments for some cancers. Swainsonine's activity against tumors is attributed to its stimulation of macrophages. In mice, swainsonine reduces the toxicity of doxorubicin, suggesting that swainsonine might enable use of higher doses of doxorubicin. Swainsonine may promote restoration of bone marrow damaged by some types of cancer treatments.

More Information
Alternate Name/Synonyms
SWAINSONINE, 8A,B-INDOLIZIDINE-1,2A,8B-TRIOL, (1S,2R,8R,8aR)-octahydro-1,2,8indolizinetriol, Tridolgosir, (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol, SwainMoia, D-Swainsonine
SKU
S-3351
CAS #
72741-87-8
Chemical Formula
C8H15NO3
Molecular Weight
173.20 Da
Appearance
White powder
Purity
98%
Solubility
Water: Clear colorless solubility at 10mg/ml; Methanol: Clear colorless solution at 5 mg/ml
Storage Temp
Store desiccated at -20°C.
THERAPEUTIC AREA
Immunotherapy
Handling
Open container carefully. Use the original container to store the product. Keep lid tightly closed, avoid exposing to strong direct light. Other Vendors may recommend higher temperatures for storage. Protect from moisture!
Hazard Image
Yes
Certificate of Analysis 1
GHS PICTOGRAMS
HandlingOpen container carefully. Use the original container to store the product. Keep lid tightly closed, avoid exposing to strong direct light. Other Vendors may recommend higher temperatures for storage. Protect from moisture!
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