Syk Inhibitor

SKU
S-2449
  • CAS:622387-85-3
  • Formula:C18H15N3O3S
  • MW:353.39
  • Appearance:Orange Solid
  • Purity:97% by HPLC
Product Name Qty
Syk Inhibitor
1 mg
$68.34
Syk Inhibitor
5 mg
$222.12
Cell-permeable. An oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC= 14 nM). Has been shown to effectively inhibit FcRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC= 313 nM).
More Information
Alternate Name/Synonyms
Spleen Tyrosine Kinase Inhibitor
SKU
S-2449
CAS #
622387-85-3
Chemical Name
3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
Chemical Formula
C18H15N3O3S
Molecular Weight
353.39
Appearance
Orange Solid
Purity
97% by HPLC
Solubility
DMSO
Melting Point
258.51 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Syk Inhibitor is an oxindole compound that acts to effectively inhibit FcεRI-mediated degranulation in RBL-2H3. Syk Inhibitor is an inhibitor of Syk
MDL NUMBER
MFCD07776820
CHEMACX
X1562673-0
INCHI
InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-
SMILES
Cn1cc(c2c1cccc2)/C=C\3/c4cc(ccc4NC3=O)S(=O)(=O)N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and mositure
Handling Protect from light and mositure
UN #'S Not Applicable
Packing Group Not Applicable
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