SDS
CofA
Cell-permeable. A potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase (IC= 6 nM). Displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo.
More Information
Alternate Name/Synonyms
(E)-4-((4-)1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-trifluoromethyl)oxazole; Mubritinib
SKU
T-2450
CAS #
366017-09-6
Chemical Name
(E)-4-((4-)1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-trifluoromethyl)oxazole; Mubritinib
Chemical Formula
C25H23F3N4O2
Molecular Weight
468.47
Appearance
White to off-white Solid
Purity
98% by HPLC
Solubility
DMSO (~25 mg/ml) or EtOH (~ 1.7 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A selective, potent, and irreversible ErbB2 and EGFR inhibitor use in cancer
MDL NUMBER
MFCD09954135
CHEMACX
X1722551-1
INCHI
InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
SMILES
c1cc(ccc1CCCCn2ccnn2)OCc3coc(n3)/C=C/c4ccc(cc4)C(F)(F)F
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and air
| Handling | Protect from light and air |
|---|---|
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
