Teicoplanin A2-1

SKU
T-2577
  • CAS:91032-34-7
  • Formula:C88H95Cl2N9O33
  • MW:1877.7
  • Appearance:White solid
  • Purity:>98% by HPLC
Product Name Qty
Teicoplanin A2-1
1 mg
$264.51
Teicoplanin A2-1
5 mg
$925.22

Teicoplanin A2-1 is a glycopeptide antibiotic obtained from actinomycetes Actinoplanes teichomyceticus isolated from soil in India. Teicoplanin A2-1 is a mixture of related glycopeptide analogues, with a basic structure characterized with a linear heptapeptide, the distinct carbohydrates D-mannose and D-glycosamine and acyl residue that carries various fatty acids which define the members of the teicoplanin complex. It shows appreciable activity against staphylococci and streptococci, corynebacteria, listeria, and clostridia. It inhibits cell wall biosynthesis in gram-positive organisms by interfering with peptidoglycan polymerization. Teicoplanin A2-1 also fights methicillinresistant Staphylococcus aureus (MRSA).

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More Information
Alternate Name/Synonyms
Targocid, Ticosin, Antibiotic L 17054
SKU
T-2577
CAS #
91032-34-7
Chemical Formula
C88H95Cl2N9O33
Molecular Weight
1877.7
Appearance
White solid
Purity
>98% by HPLC
Solubility
Soluble in DMSO, DMF, ethanol, methanol, and water (poorly)
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
A glycopeptide antibiotic produced by Actinoplanes teichomyceticus
INCHI
InChI=1S/C88H95Cl2N9O33/c1-3-4-5-6-7-8-9-10-60(108)94-68-74(113)71(110)58(32-101)129-87(68)132-78-55-26-40-27-56(78)126-52-18-14-38(24-47(52)90)77(131-86-67(92-34(2)103)73(112)70(109)57(31-100)128-86)69-84(121)98-66(85(122)123)45-29-42(105)30-54(127-88-76(115)75(114)72(111)59(33-102)130-88)61(45)44-23-37(13-15-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-21-41(104)28-43(22-39)124-53-25-36(12-16-50(53)107)62(91)80(117)93-48(79(116)95-64)20-35-11-17-51(125-55)46(89)19-35/h7-8,11-19,21-30,48,57-59,62-77,86-88,100-102,104-107,109-115H,3-6,9-10,20,31-33,91H2,1-2H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/b8-7-/t48-,57-,58-,59-,62+,63-,64+,65-,66-,67-,68-,69+,70-,71-,72-,73-,74-,75+,76+,77-,86+,87+,88+/m1/s1
SMILES
CCCCC/C=C\CCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1Oc2c3cc4cc2Oc5ccc(cc5Cl)[C@H]([C@H]6C(=O)N[C@H](c7cc(cc(c7-c8cc(ccc8O)[C@H](C(=O)N6)NC(=O)[C@@H]4NC(=O)[C@@H]9c1cc(cc(c1)Oc1cc(ccc1O)[C@@H](C(=O)N[C@H](Cc1ccc(c(c1)Cl)O3)C(=O)N9)N)O)O[C@@H]1[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O)C(=O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)NC(=O)C)CO)O)O
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