Tenellin

SKU
T-2601
  • CAS:53823-15-7
  • Formula:C21H23NO5
  • MW:369.4
  • Appearance:Yellow solid
  • Purity:≥95%
Product Name Qty
Tenellin
1 mg
$341.72
Tenellin
5 mg
$1,196.02

Description

Tenellin is a yellow fungal metabolite produced by species of the genus Beauveria which belongs to the rare 4-hydroxypyridone class including a dienone side chain. The fungus causes white muscardine disease in silkworms.

It has been reported that tenellin plays an important role in iron homeostasis in the ferricrocin-deficient Beauveria bassiana. It downregulates the toxicity of iron-generated reactive oxygen species by working as an iron chelator in ferricrocin-deficient mutants Beauveria bassiana.

It suppresses Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes and is cytotoxic to Sf9 and Sf21 insect cells.

 

Applications

• Biocontrol agent

• Iron chelator in ferricrocin-deficient mutant Beauveria bassiana

  

References

“Bio-Pesticides: Application and Possible Mechanism of Action”

“Tenellin acts as an iron chelator to prevent iron-generated reactive oxygen species toxicity in the entomopathogenic fungus Beauveria bassiana”

“BIOACTIVE METABOLITES OF ENTOMOPATHOGENIC FUNGI Beauveria bassiana”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

 

More Information
Alternate Name/Synonyms
3-[(2E,4E,6R)-4,6-dimethyl-1-oxo-2,4-octadien-1-yl]-1,4-dihydroxy-5-(4-hydroxyphenyl)-2(1H)-pyridinone; UNII-9E0EXM5N1D
SKU
T-2601
CAS #
53823-15-7
Chemical Name
3-[(2E,4E)-4,6-dimethylocta-2,4-dienoyl]-1,4-dihydroxy-5-(4-hydroxyphenyl)pyridin-2-one
Chemical Formula
C21H23NO5
Molecular Weight
369.4
Appearance
Yellow solid
Purity
≥95%
Solubility
Soluble in ethanol, methanol, DMF and DMSO.
Storage Temp
-20°C
USE
Tenellin is used as a biocontrol agent for pests.
INCHI
InChI=1S/C21H23NO5/c1-4-13(2)11-14(3)5-10-18(24)19-20(25)17(12-22(27)21(19)26)15-6-8-16(23)9-7-15/h5-13,23,25,27H,4H2,1-3H3/b10-5+,14-11+
SMILES
CCC(C)/C=C(\C)/C=C/C(=O)c1c(c(cn(c1=O)O)c2ccc(cc2)O)O
Handling
Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure.
Certificate of Analysis 1
Handling Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure.
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