Tetranactin

SKU

T-2617

CAS:33956-61-5
Formula:C₄₄H₇₂O₁₂
MW:793 Da
Appearance:White solid
Purity:>95% by HPLC

SDS

CofA

Product Name	Qty
Tetranactin 1 mg $341.72
Tetranactin 5 mg $1,196.02

Details

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Description

Tetranactin is a macrotetrolide produced by Streptomyces aureus. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. It is demonstrated to inhibit synthesis and release of IL-2 by mitogen-activated lymphocytes and it shows immunosuppressive effects by affecting intracellular cation concentrations.

It has antibacterial, insecticidal and mitogenic activities. The antibiotic suppresses the growth of Gram-positive bacteria and some phytopathogenic fungi in vitro at low concentrations.

Tetranactin ionophore has limited water solubility but is soluble in most organic solvents.

Applications

• Monovalent cation ionophore

• Antibiotic

• Immunosuppressive agent

References

• “Tetranactin, A New Miticidal Antibiotic”

• “Immunosuppressive and anti-proliferative effects of a macrotetrolide antibiotic, tetranactin”

• “Tetranactin, a macrotetrolide antibiotic, suppresses in vitro proliferation of human lymphocytes and generation of cytotoxicity”

Not for human therapeutic use or for medicinal purposes. For research applications only.

Specifications

More Information

SKU

T-2617

CAS #

33956-61-5

Chemical Name

(1S,2S,5S,7S,10R,11R,14R,16R,19S,20S,23S,25S,28R,29R,32R,34R)-5,14,23,32-tetraethyl-2,11,20,29-tetramethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone

Chemical Formula

C₄₄H₇₂O₁₂

Molecular Weight

793 Da

Appearance

White solid

Purity

>95% by HPLC

Solubility

Soluble in ethanol, water (limited), methanol, DMF, and DMSO

Storage Temp

-20°C

THERAPEUTIC AREA

Immunosuppressive drug

USE

Tetranactin exhibits potent insecticidal, mitogenic, antibacterial activity

MDL NUMBER

MFCD01711666

INCHI

InChI=1S/C44H72O12/c1-9-29-21-33-13-17-38(49-33)26(6)42(46)54-31(11-3)23-35-15-19-40(51-35)28(8)44(48)56-32(12-4)24-36-16-20-39(52-36)27(7)43(47)55-30(10-2)22-34-14-18-37(50-34)25(5)41(45)53-29/h25-40H,9-24H2,1-8H3/t25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,38+,39+,40-

SMILES

CC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C(=O)O[C@@H](C[C@H]3CC[C@H](O3)[C@@H](C(=O)O[C@H](C[C@@H]4CC[C@@H](O4)[C@H](C(=O)O[C@@H](C[C@H]5CC[C@H](O5)[C@@H](C(=O)O1)C)CC)C)CC)C)CC)C

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