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Tetranactin

SKU
T-2617
  • CAS:33956-61-5
  • Formula:C44H72O12
  • MW:793 Da
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Tetranactin
1 mg
$349.58
Tetranactin
5 mg
$1,223.53
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Description

Tetranactin is a macrotetrolide produced by Streptomyces aureus. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. It is demonstrated to inhibit synthesis and release of IL-2 by mitogen-activated lymphocytes and it shows immunosuppressive effects by affecting intracellular cation concentrations.

It has antibacterial, insecticidal and mitogenic activities. The antibiotic suppresses the growth of Gram-positive bacteria and some phytopathogenic fungi in vitro at low concentrations.

Tetranactin ionophore has limited water solubility but is soluble in most organic solvents.

 

Applications

• Monovalent cation ionophore

• Antibiotic

• Immunosuppressive agent

 

References

• “Tetranactin, A New Miticidal Antibiotic”

• “Immunosuppressive and anti-proliferative effects of a macrotetrolide antibiotic, tetranactin”

• “Tetranactin, a macrotetrolide antibiotic, suppresses in vitro proliferation of human lymphocytes and generation of cytotoxicity”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
SKU
T-2617
CAS #
33956-61-5
Chemical Name
(1S,2S,5S,7S,10R,11R,14R,16R,19S,20S,23S,25S,28R,29R,32R,34R)-5,14,23,32-tetraethyl-2,11,20,29-tetramethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
Chemical Formula
C44H72O12
Molecular Weight
793 Da
Appearance
White solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, water (limited), methanol, DMF, and DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Immunosuppressive drug
USE
Tetranactin exhibits potent insecticidal, mitogenic, antibacterial activity
MDL NUMBER
MFCD01711666
INCHI
InChI=1S/C44H72O12/c1-9-29-21-33-13-17-38(49-33)26(6)42(46)54-31(11-3)23-35-15-19-40(51-35)28(8)44(48)56-32(12-4)24-36-16-20-39(52-36)27(7)43(47)55-30(10-2)22-34-14-18-37(50-34)25(5)41(45)53-29/h25-40H,9-24H2,1-8H3/t25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,38+,39+,40-
SMILES
CC[C@H]1C[C@@H]2CC[C@@H](O2)[C@H](C(=O)O[C@@H](C[C@H]3CC[C@H](O3)[C@@H](C(=O)O[C@H](C[C@@H]4CC[C@@H](O4)[C@H](C(=O)O[C@@H](C[C@H]5CC[C@H](O5)[C@@H](C(=O)O1)C)CC)C)CC)C)CC)C
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