Tetromycin B

SKU
T-2621
  • CAS:180027-84-3
  • Formula:C34H46O5
  • MW:534.7
  • Appearance:Light tan solid
  • Purity:>99% by HPLC
Product Name Qty
Tetromycin B
0.5 mg
$310.51
Tetromycin B
2.5 mg
$1,055.74
*Please inquire the availability for this product. Tetromycin B is an unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin B has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway.
More Information
SKU
T-2621
CAS #
180027-84-3
Chemical Formula
C34H46O5
Molecular Weight
534.7
Appearance
Light tan solid
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF, DMSO, and water (moderately)
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Tetromycin B has displayed pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA
MDL NUMBER
MFCD00950447
INCHI
InChI=1S/C34H46O5/c1-18-10-9-11-19(2)27-21(4)14-24-25(35)13-12-20(3)28(24)33(27,8)29(36)26-30(37)34(39-31(26)38)17-23(6)22(5)16-32(34,7)15-18/h11,14-16,20,23-25,27-28,35,37H,9-10,12-13,17H2,1-8H3/b18-15+,19-11+
SMILES
CC1CCC(C2C1C3(C(/C(=C/CC/C(=C/C4(C=C(C(CC45C(=C(C3=O)C(=O)O5)O)C)C)C)/C)/C)C(=C2)C)C)O
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