SDS
CofA
Description
Thalidomide binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A inhibiting ligase activity. Inhibits TNFα synthesis and FGF-induced angiogenesis. Cell permeable.
Caution: Teratogenic. Pregnant women should avoid using this compound.
References
• Identification of a Primary Target of Thalidomide Teratogenicity
• Inhibition of tumor necrosis factor-alpha by thalidomide in magnesium deficiency
• Thalidomide is an inhibitor of angiogenesis
Not for human therapeutic use or for medicinal purposes. For research applications only.
More Information
Alternate Name/Synonyms
(+/-)-Thalidomide; Thalomid; N-(2,6-dioxo-3-piperidinyl)phthalimide (racemic); Sedoval; Corronarobetin
SKU
T-1020
CAS #
50-35-1
Chemical Name
2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Chemical Formula
C13H10N2O4
Molecular Weight
258.2
Appearance
White powder
Purity
>98%
Solubility
May be dissolved in DMSO
Melting Point
269-271ºC
Storage Temp
Room temperature
THERAPEUTIC AREA
Oncological Disorders
USE
A selective inhibitor of TNF alpha biosynthesis shown to have immunomodulatory and antiangeogenic activity
Merck Index
13.9326.2001
MDL NUMBER
MFCD00153873
CHEMACX
X1002033-8
INCHI
InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
SMILES
c1ccc2c(c1)C(=O)N(C2=O)C3CCC(=O)NC3=O
RTECS
TI4375000
UN #'S
UN 2811
PACKING GROUP
III
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product.
Special Shipping
Yes
Certificate of Analysis 1
Certificate of Analysis 2
| GHS PICTOGRAMS |   |
|---|---|
| Handling | Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. |
| UN #'S | UN 2811 |
| Packing Group | III |
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