Bryamycin; NSC 81722; NSC 170365; Thiactin; Thiostreptin A
1393-48-2
1664.9
C72H85N19O18S5
DMF, DMSO, DMF:PBS (pH 7.2) (1:1)
-20°C
Thiostrepton is a thiazole-containing peptide antibiotic from Streptomyces. It is generally used for Gram-negative and Gram-positive bacteria and is employed as a selective marker for recombinant DNA/plasmid technologies.
The thiazole antibiotic inhibits protein synthesis by preventing binding of elongation factor G (EF-G) and GTP to 50S ribosomal subunit and affects the function of initiation factor IF2.
Thiostrepton has shown anticancer properties such as induction of apoptosis and suppression of cell growth in human cancer cells. For example, it blocks expression of FoxM1-regualted genes and thus suppresses the transcription factor, FoxM1, which is related to cell proliferation and commonly overexpressed in tumor cell lines. This antibiotic arrests cell cycle at G1 and S phases and induces cell death in cancer cells.
Applications:
• Selective marker for recombinant DNA/plasmid technology
• Protein synthesis inhibitor
• Inhibition of FoxM1 expression in cancer cells
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
