- MW:1664.89 Da
- Appearance:White to Off-white powder
- Purity:>90% (HPLC)
Thiostreptin is a thiazole-containing peptide antibiotic used in molecular biology applications. The thiostrepton-resistant gene is commonly used as a selective marker for recombinant DNA/plasmid technologies. Thiostrepton inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. Activation of TLR7–9 has been linked to autoimmune diseases such as rheumatoid arthritis, lupus, and psoriasis. Thiostrepton has been shown to be a novel TLR7–9 inhibitor1. Thiostrepton inhbits FoxM1 which ultimately suppresses tumor formation in ovarian cancer cells2.
|Handling||Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.|