SDS
CofA
A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 μM). Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).
More Information
SKU
T-1252
CAS #
1049741-03-8
Chemical Name
6,7-Dimethyl-3-((methyl-(2-(methyl-(1-3-trifuluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCI, Tumor Necrosis Factor-α Inhibitor
Chemical Formula
C32H32F3N3O2 2HCI •1/2H2O
Molecular Weight
629.6
Appearance
White Solid
Purity
≥95% by HPLC
Solubility
DMSO
Storage Temp
-20°C
Certificate of Analysis 1
