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TNF-α Inhibitor

SKU
T-1252
  • CAS:1049741-03-8
  • Formula:C32H32F3N3O2  2HCI •1/2H2O
  • MW:629.6
  • Appearance:White Solid
  • Purity:≥95% by HPLC
Product Name Qty
TNF-α Inhibitor
5 mg
$256.29
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A cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α  trimer and promotin sbunit dissociation and preventing TNF-α  binding to its receptor (IC50 = 22 μM).  Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).

More Information
SKU
T-1252
CAS #
1049741-03-8
Chemical Name
6,7-Dimethyl-3-((methyl-(2-(methyl-(1-3-trifuluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCI, Tumor Necrosis Factor-α Inhibitor
Chemical Formula
C32H32F3N3O2  2HCI •1/2H2O
Molecular Weight
629.6
Appearance
White Solid
Purity
≥95% by HPLC
Solubility
DMSO
Storage Temp
-20°C
Certificate of Analysis 1
T-1252, E1137.pdf
Citations Curcumin requires tumor necrosis factor α signaling to alleviate cognitive impairment elicited by lipopolysaccharide
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