Tozasertib

SKU
T-2466
  • CAS:639089-54-6
  • Formula:C23H28N8OS
  • MW:464.59
  • Appearance:White to off-white Solid
  • Purity:99% by HPLC
Product Name Qty
Tozasertib
100 mg
$336.03
Tozasertib
25 mg
$108.21
Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.
More Information
Alternate Name/Synonyms
MK-0457, VX6, VX-681
SKU
T-2466
CAS #
639089-54-6
Chemical Name
N-(4-(4-(3-METHYL-1H-PYRAZOL-5-YLAMINO)-6-(4-METHYLPIPERAZIN-1-YL)PYRIMIDIN-2-YLTHIO)PHENYL)CYCLOPROPANECARBOXAMIDE
Chemical Formula
C23H28N8OS
Molecular Weight
464.59
Appearance
White to off-white Solid
Purity
99% by HPLC
Solubility
DMSO (100 mg/ml)
Melting Point
245-260 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Tozasertib is a potent pan-ARK inhibitor but favors ARK-1.Tozasertib effectively inhibits proliferation of renal carcinoma
MDL NUMBER
MFCD13185152
CHEMACX
X1653617-5
INCHI
InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
SMILES
Cc1cc(n[nH]1)Nc2cc(nc(n2)Sc3ccc(cc3)NC(=O)C4CC4)N5CCN(CC5)C
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
HandlingProtect from light and moisture
UN #'SNot Applicable
Packing GroupNot Applicable
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