Trehalose Dihydrate

SKU
T-2677
  • CAS:6138-23-4
  • Formula:C12H22O11 • 2H2O
  • MW:378.3 Da
  • Appearance:White to off-white crystalline powder
  • Purity:≥98%
Product Name Qty
D-(+)-Trehalose Dihydrate
25 g
$46.18
D-(+)-Trehalose Dihydrate
50 g
$70.01
D-(+)-Trehalose Dihydrate
100 g
$99.70

Trehalose is a sugar consisting of 2 glucose molecules. Also known as mycose or tremalose, this sugar is synthesized by some bacteria, fungi, plants and invertebrates as a source of energy as well as to survive freezing and lack of water.  It is among the most effective sugars for the stabilization of proteins against damage caused by desiccation or freezing and is noted for its high water-retention capabilities, protecting cells against multiple environmental stressors. It is rarely used as a replacement for conventional sweeteners. It is more commonly used as a cryoprotectant in a variety of cell freezing media. A wide array of implemental enzymes, probes, substrates, antibodies and biology reagents can be kept in trehalose, saving on expensive freezer storage.

D-(+)-Trehalose dihydrate is a non-reducing disaccharide, yielding 2 moles of D-glucose upon acid hydrolysis. It is an inducer of autophagy and has properties allowing it to stabilize partially unfolded proteins and inhibit protein aggregation. Trehalose dihydrate has been demonstrated to decrease lysosomal amyloid precursor protein (APP) and inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. This sugar is known to accumulate in osmotically-stressed bacterial cultures and protects against the adverse effects of dehydration. Trehalose dihydrate demonstrates a low chemical reactivity, is non-reducing, and has a high affinity for water molecules.

 

More Information
Alternate Name/Synonyms
D-(+)-Trehalose Dihydrate; alpha-D-glucopyranosyl-alpha; Mycose; Tremalose; D-Trehalose dihydrate
SKU
T-2677
CAS #
6138-23-4
Chemical Name
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate
Chemical Formula
C12H22O11 • 2H2O
Molecular Weight
378.3 Da
Appearance
White to off-white crystalline powder
Purity
≥98%
Solubility
Soluble in water (100 mg/mL) and hot alcohol
Melting Point
97-99° C
Storage Temp
Room temperature
USE
For laboratory and research purpose only.
PubChecm ID
181978
INCHI
DPVHGFAJLZWDOC-PVXXTIHASA-N
SMILES
C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O.O.O
HAZARD CLASS
Not a hazardous substance or mixture.
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
HandlingUse only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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