Trifluorothymidine

SKU
T-2831
  • CAS:70-00-8
  • Formula:C10H11F3N2O5
  • MW:296.2
  • Appearance:Off-white powder
  • Purity:>98% by HPLC

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Product Name Qty
Trofluorothymidine
50 mg
$22.00
Trifluorothymidine
250 mg
$90.00

Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase. TFT also inhibits thymidylate synthase (TS), a rate-limiting enzyme of DNA biosynthesis, and is incorporated into DNA.

Nucleoside antimetabolite/analog Trifluorothymidine (TFT) is well known to be converted to TFT-monophosphate by thymidine kinase and to inhibit thymidylate synthase in vitro.

Unlike FdUrd and 5FU, TFT resulted in an earlier phosphorylation of ATR and chk1 proteins after only 24 h of exposure, while phosphorylated ATM, BRCA2 and chk2 proteins were detected after more than 48 h of exposure to TFT. SN38 and TFT induced most DNA damage in H630 and Colo320 cells, which was increased in combination. TFT pre-incubation further enhanced SN38-induced DNA strand breaks in H630 and Colo320 (>20%), which was most pronounced in H630 cells (p<0.01). in vivo: After oral administration of TFT in rats, more than 75% of the TFT was absorbed. 

TFT enhances TRAIL-induced apoptosis in NSCLC cells by sensitizing the apoptotic machinery at different levels in the TRAIL pathway. 

More Information
Alternate Name/Synonyms
2′-Deoxy-5-trifluoromethyluridine; Trifluorothymine deoxyriboside; α,α,α-Trifluorothymidine; Trifluridine, TFT
SKU
T-2831
CAS #
70-00-8
Chemical Formula
C10H11F3N2O5
Molecular Weight
296.2
Appearance
Off-white powder
Purity
>98% by HPLC
Solubility
May be dissolved in DMSO (50 mg/ml); or water (14 mg/ml).
Storage Temp
Store desiccated as supplied at -20°C for up to two years. Store solutions at -20°C for up to 1 month.
Hazard Image
Yes
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