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Price$ 151.75
  • SKU: T-2471-1MG
  • Pack Size: 1 MG
Quantity
-
+

537049-40-4

721.9

C41H43N3O7S

DMF, DMSO

-20°C


Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC= 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6.

Tubacin causes increased acetylation of tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated tubulin deacetylation in mammalian cells.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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