Tubacin

SKU
T-2471
  • CAS:537049-40-4
  • Formula:C41H43N3O7S
  • MW:721.86
  • Appearance:Off-White Solid
  • Purity:98% by HPLC
Product Name Qty
Tubacin
1 mg
$256.29
Tubacin
250 g
$96.82
Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC= 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated tubulin deacetylation in mammalian cells.
More Information
Alternate Name/Synonyms
N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
SKU
T-2471
CAS #
537049-40-4
Chemical Name
N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Chemical Formula
C41H43N3O7S
Molecular Weight
721.86
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO (~ 10 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A selective inhibitor of HDAC6 induces DNA damage and sensitizes transformed cells to anticancer agents
MDL NUMBER
MFCD18452824
CHEMACX
X1851075-3
INCHI
InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
SMILES
c1ccc(cc1)c2c(oc(n2)SC[C@H]3C[C@H](O[C@H](O3)c4ccc(cc4)NC(=O)CCCCCCC(=O)NO)c5ccc(cc5)CO)c6ccccc6
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and mositure
HandlingProtect from light and mositure
UN #'SNot Applicable
Packing GroupNot Applicable
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