Tunicamycin

SKU
T-1016
  • CAS:11089-65-9
  • Formula:C39H64N4O16
  • MW:840.0 Da
  • Appearance:White to off-white powder
  • Purity:≥98%

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Product Name Qty
Tunicamycin
10 mg
$204.56
Tunicamycin
50 mg
$779.51

Tunicamycin is an antibiotic isolated from Streptomyces Iysosuperficus useful in glycoprotein research. This compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts, and viruses. It is an inhibitor of N-linked glycosylation and the formation of N-glycosidic protein-carbohydrate linkages. During protein glycosylation, tunicamycin is noted to inhibit the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.

 

 

 

More Information
SKU
T-1016
CAS #
11089-65-9
Chemical Name
(E)-N-[(2S,3R,4R,5R,6R)-2-[(2R,3R,4R,5S,6R)- 3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy- 6-[2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)- 3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan- 3-yl]-5-methylhex-2-enamide
Chemical Formula
C39H64N4O16
Molecular Weight
840.0 Da
Appearance
White to off-white powder
Purity
≥98%
Solubility
DMSO: Clear colorless solution at 50 mg/mL ,Ethanol: Clear colorless solution at 5 mg/mL, warm
Melting Point
248-250°C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
As a member of a family of antibiotics produced by Streptomyces lysosuperficus, tunicamycin is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells.
Merck Index
13.6888.2001
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Citations
MOLECULAR BASIS OF CELL AND DEVELOPMENTAL BIOLOGY: Prosurvival and Prodeath Effects of Hypoxia-inducible Factor-1Stabilization in a Murine Hippocampal Cell Line Leila R. Aminova, Juan C. Chavez, Junghee Lee, Hoon Ryu, Andrew Kung, Joseph C. LaManna, and Rajiv R. Ratan J. Biol. Chem., Feb 2005; 280: 3996 - 4003.
Citations_Hyperlink
http://www.jbc.org/cgi/reprint/280/5/3996
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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