U-74389G

SKU
U-2562
  • CAS:153190-29-5
  • Formula:C37H50N6O2.C4H4O4
  • MW:726.9
  • Appearance:Chrystalline Solid
  • Purity:>99%
Product Name Qty
U-74389G
100 mg
$108.21

Lazaroid U-74389G (LAZ) is a 21-aminosteroid that has radioprotective effects against radiation-induced lipid peroxidation. Researchers utilized a liposomal formulation to evaluate LAZ radioprotective and antiproliferative effects in a glioblastoma mouse model. LAZ liposomal formulations reduced tumor growth by 65%. LAZ also protected brain tissue from radiation-induced lipid peroxidation by reducing MDA concentration by 50%1.

Novel antioxidant compounds, the pyrrolopyrimidines, has been discovered, possess increased efficacy & potency in protecting cultured neurons against iron-induced lipid peroxidative injury and as much as a 5-fold increase in brain uptake compared with U-74006G. They appear to quench lipid peroxidation reactions by electron-donating and/or radical-trapping mechanisms2.

Increased levels of oxidative damage to DNA, lipids and proteins have been detected by a range of assays in post-mortem tissues from patients with Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis, and at least some of these changes may occur early in disease progression.

U-74006F appears to localize in the blood-brain barrier. Studies have demonstrated that lymphocyte-derived microparticles (LMPs) impair endothelial cell function. The antioxidant U-74389G were partially protective against the antiproliferative effects of LMPs3.

More Information
Alternate Name/Synonyms
Methylated Tirilazad
SKU
U-2562
CAS #
153190-29-5
Chemical Formula
C37H50N6O2.C4H4O4
Molecular Weight
726.9
Appearance
Chrystalline Solid
Purity
>99%
Solubility
Soluble in DMSO(~1mg/ml), Ethanol(~35mg/ml), and DMF(~36mg/ml)
Storage Temp
-20C
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