• CAS:109522-58-2
  • Formula:C18H16N6S2
  • MW:380.5
  • Appearance:White Solid
  • Purity:>98%
Product Name Qty
1 mg
5 mg

Potent and specific inhibitor of MEK1 and MEK2.Blocks the production of inflammatory cytokines and matrix metalloproteinases. Does not inhibit PKA, PKC or CaM KII.


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Chemical Formula
Molecular Weight
White Solid
DMSO (~ 8 mg/ml)
Storage Temp
THERAPEUTIC DISCOVERY: Galectin-3 Promotes Chronic Activation of K-Ras and Differentiation Block in Malignant Thyroid Carcinomas Ran Levy, Meital Grafi-Cohen, Zaki Kraiem, and Yoel Kloog Mol. Cancer Ther., Aug 2010; 9: 2208 - 2219.
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CitationsGalectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas
Thromboxane A2 receptor α promotes tumor growth through an autoregulatory feedback pathway
Estrogen receptor alpha promotes smoking-carcinogen-induced lung carcinogenesis via cytochrome P450 1B1
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
Melatonin inhibits visfatin-induced inducible nitric oxide synthase expression and nitric oxide production in macrophages
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Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity
Generation of human secondary cardiospheres as a potent cell processing strategy for cell-based cardiac repair
MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis
Secondary sphere formation enhances the functionality of cardiac progenitor cells
Mast cells are directly activated by contact with cancer cells by a mechanism involving autocrine formation of adenosine and autocrine/paracrine signaling of the adenosine A3 receptor
IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus
MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death
Visfatin promotes cell and tumor growth by upregulating Notch1 in breast cancer
Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways
Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells
Folic acid inhibits colorectal cancer cell migration
The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury
Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the pituitary gonadotropes
Regulation of myosin light chain kinase expression by angiotensin II in hypertension
Actin Dysfunction Activates ERK1/2 and Delays Entry into Mitosis in Mammalian Cells
Bone morphogenetic protein 4 stimulates attachment of neurospheres and astrogenesis of neural stem cells in neurospheres via phosphatidylinositol 3 kinase-mediated upregulation of N-cadherin
A Protoberberine derivative HWY336 selectively inhibits MKK4 and MKK7 in mammalian cells: the importance of activation loop on selectivity
Prolactin stimulates the L-type calcium channel-mediated transepithelial calcium transport in the duodenum of male rats
Angiogenic role of orexin-A via the activation of extracellular signal-regulated kinase in endothelial cells
Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin-angiotensin system
A dual altered peptide ligand inhibits myasthenia gravis associated responses by inducing phosphorylated extracellular-regulated kinase 1,2 that upregulates CD4+CD25+Foxp3+ cells
The extra-cellular signal regulated kinases ERK1 and ERK2 segregate displaying distinct spatiotemporal characteristics in activated mast cells
The generation of cardiosphere from adult heart and the implication of LPAR4+ cardiac progenitor cells for the treatment in ischemic heart disease
Actin-binding protein 1 and Dynamin-2 modulate attenuation of B-cell signaling and regulate B-cell function
Mecanismos moleculares envolvidos na diferenciação das SHED (Stem Cells from Exfoliated Deciduous Teeth) em células endoteliais
Basic fibroblast growth factor による培養ヒト皮膚線維芽細胞の増殖刺激機序の検討
Prolactin-stimulated transepithelial calcium transport in duodenum and Caco-2 monolayer are mediated by the phosphoinositide 3-kinase pathway
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1
p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
NF-kappaB activation stimulates osteogenic differentiation of mesenchymal stem cells derived from human adipose tissue by increasing TAZ expression
Mast Cells Are Directly Activated by Cancer Cell-Derived Extracellular Vesicles by a CD73- and Adenosine-Dependent Mechanism
Assessing the effects of cyclosporine A on the osteoblastogenesis, osteoclastogenesis, and angiogenesis mediated by the human periodontal ligament stem cells
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