Umirolimus

SKU
U-2581
  • CAS:851536-75-9
  • Formula:C55H87NO14
  • MW:986.3
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Umirolimus
1 mg
$115.03
Umirolimus
5 mg
$403.14
*Please inquire the availability for this product. Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to suppress localised immunoreaction. Like all tacrolimus analogues, umirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR and prevents it from interacting with target proteins. Umirolimus is extensively cited in the literature with over 70 citations.
More Information
Alternate Name/Synonyms
Biolimus, Biolimus A9, TRM 986
SKU
U-2581
CAS #
851536-75-9
Chemical Name
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-12-((2R)-1-[(1S,3R,4R)-4-(2-ETHOXYETHOXY)-3-METHOXYCYCLOHEXYL]-2-PROPANYL)-1,18-DIHYDROXY-19,30-DIMETHOXY-15,17,21,23,29,35-HEXAMETHYL-11,36-DIO XA-4-AZATRICYCLO[30.3.1.04,9]HEXATRIACONTA-16,24,26,28
Chemical Formula
C55H87NO14
Molecular Weight
986.3
Appearance
White solid
Purity
>95% by HPLC
Stability
N/A
Storage Temp
-20
THERAPEUTIC AREA
Oncological Disorders
USE
Use of umirolimus for treating cancer
MDL NUMBER
MFCD22124433
INCHI
InChI=1S/C55H87NO14/c1-12-67-26-27-68-45-24-22-41(31-48(45)65-10)30-37(5)47-33-44(57)36(4)29-39(7)50(59)51(66-11)49(58)38(6)28-34(2)18-14-13-15-19-35(3)46(64-9)32-42-23-21-40(8)55(63,70-42)52(60)53(61)56-25-17-16-20-43(56)54(62)69-47/h13-15,18-19,29,34,36-38,40-43,45-48,50-51,59,63H,12,16-17,20-28,30-33H2,1-11H3/b15-13+,18-14+,35-19+,39-29+/t34-,36-,37-,38-,40-,41+,42+,43+,45-,46+,47+,48-,50-,51+,55-/m1/s1
SMILES
CCOCCO[C@@H]1CC[C@H](C[C@H]1OC)C[C@@H](C)[C@@H]2CC(=O)[C@@H](/C=C(/[C@H]([C@H](C(=O)[C@@H](C[C@@H](/C=C/C=C/C=C(/[C@H](CC3CC[C@H]([C@@](O3)(C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)O)C)OC)\C)C)C)OC)O)\C)C
Certificate of Analysis 1
Promo text for AGS discount
N/A
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