Vandetanib

SKU
V-2475
  • CAS:443913-73-3
  • Formula:C22H24BrFN4O2
  • MW:475.35
  • Appearance:White Solid
  • Purity:98% by HPLC
Product Name Qty
Vandetanib
25 mg
$108.21
Vandetanib
100 mg
$324.64

A potent inhibitor of kinase insert domain-containing receptor [KDR/vascular endothelial growth factor receptor (VEGFR) 2] tyrosine kinase activity (IC= 40 nM). This compound also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC= 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC= 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases.

More Information
Alternate Name/Synonyms
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima
SKU
V-2475
CAS #
443913-73-3
Chemical Name
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima
Chemical Formula
C22H24BrFN4O2
Molecular Weight
475.35
Appearance
White Solid
Purity
98% by HPLC
Solubility
DMSO (30 mg/ml) or EtOH (10 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families
MDL NUMBER
MFCD07772346
CHEMACX
X1614613-9
INCHI
InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
SMILES
CN1CCC(CC1)COc2cc3c(cc2OC)c(ncn3)Nc4ccc(cc4F)Br
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and moisture
Handling Protect from air and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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