VEGFR2 Kinase Inhibitor I

SKU
V-1082
  • CAS:15966-93-5
  • Formula:C18H18N2O3
  • MW:310.4
  • Appearance:Yellow Solid
  • Purity:95%
Product Name Qty
VEGFR2 Kinase Inhibitor I
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A highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. Does not inhibit PDGFR, EGFR, and IGF-1 tyrosine kinase activities (IC 100 M).
More Information
Alternate Name/Synonyms
(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one
SKU
V-1082
CAS #
15966-93-5
Chemical Name
(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one
Chemical Formula
C18H18N2O3
Molecular Weight
310.4
Appearance
Yellow Solid
Purity
95%
Solubility
Soluble in DMSO (10 mg/ml) or Etahnol (1 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
A highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase
MDL NUMBER
MFCD04974538
CHEMACX
Not Applicable
INCHI
InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)/b13-9-
SMILES
CCOC(=O)C1=C(NC(=C1C)/C=C\2/C3=CC=CC=C3NC2=O)C
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from Light Packaged under inert gas.
Handling Protect from Light Packaged under inert gas.
UN #'S Not Applicable
Packing Group Not Applicable
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