VEGFR2 Kinase Inhibitor II

SKU
V-1080
  • CAS:288144-20-7
  • Formula:C17H15BrN2O
  • MW:343.2
  • Appearance:Brown Solid
  • Purity:95%
Product Name Qty
VEGFR2 Kinase Inhibitor II
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A membrane permeant indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor [IC = 70 nM for VEGF-R2 (KDR/Flk-1), 920 nM for PDGF-R, 4.92 M for p60c-src, and 13.3 M for FGF-R1]. The inhibition is suggested to be competitive with respect to ATP. Also inhibits VEGF-induced (IC = 100 nM) and PDGF-induced (IC = 2.01 M)cell proliferation in umbilical vein endothelial cells (HUVEC). Does not exhibit any inhibitory effect on EGF-R kinase activity (IC 100 M).
More Information
Alternate Name/Synonyms
Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor II
SKU
V-1080
CAS #
288144-20-7
Chemical Name
(Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
Chemical Formula
C17H15BrN2O
Molecular Weight
343.2
Appearance
Brown Solid
Purity
95%
Solubility
Soluble in DMSO
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Not Available
MDL NUMBER
MFCD03453583
CHEMACX
Not Applicable
INCHI
InChI=1S/C17H15BrN2O/c18-11-5-6-13-14(17(21)20-16(13)8-11)9-12-7-10-3-1-2-4-15(10)19-12/h5-9,19H,1-4H2,(H,20,21)/b14-9-
SMILES
c1cc\2c(cc1Br)NC(=O)/C2=C\c3cc4c([nH]3)CCCC4
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from Light Packaged under inert gas.
Handling Protect from Light Packaged under inert gas.
UN #'S Not Applicable
Packing Group Not Applicable
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