Vildagliptin (LAF-237)

SKU
V-2421
  • CAS:274901-16-5
  • Formula:C17H25N3O2
  • MW:303.4
  • Appearance:White Powder

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Product Name Qty
Vildagliptin
20 mg
$153.75
Vildagliptin
100 mg
$251.13

A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1)1. Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia)2. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model3. Displays protective effects on b-cells by inhibition of ER stress in a mouse model4. Clinically useful antidiabetic agent.

Vildagliptin increases β cell mass by not only directly affecting cell kinetics but also by indirectly reducing cell apoptosis, oxidative stress and endoplasmic reticulum stress in diabetic mice.

 

More Information
Alternate Name/Synonyms
(S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237; 2-Pyrrolidinecarbonitrile
SKU
V-2421
CAS #
274901-16-5
Chemical Name
(S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile
Chemical Formula
C17H25N3O2
Molecular Weight
303.4
Appearance
White Powder
Solubility
May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
USE
Laboratory chemicals, manufacture of substances.
PACKING GROUP
III
Handling
Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Certificate of Analysis 1
Handling Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Packing Group III
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