Description

Vinblastine sulfate is a plant alkaloid, arresting the cell cycle in the G2/M phase by blocking mitotic spindle formation. It suppresses normal microtubule assembly and causes abnormal tubulin polymerization. It also inhibits binding of tubulin to microtubule proteins.

The plant alkaloid is related to the apoptosis pathway. It renders Raf-1 activation, phosphorylation of Bcl-2 family proteins, and induction of p53 expression. Apoptosis in human acute promyelocytic leukemia cells (APL) is induced by vinblastine sulfate because it inhibits nuclear factor kappa B (NFκB) expression and suppresses NFκB-DNA binding activity. Also, Induction of c-Jun N-terminal kinase (JNK) activation causes apoptosis through caspase-dependent pathway.

Applications

• Cell cycle blocker

• Apoptosis inducer

• Chemotherapeutic agent

• Neurofibrillary tangles and neuronal degeneration inducer

References

• “Neurofibrillary tangles induced by vincristine and vinblastine sulfate in central and peripheral neurons in vitro”

• “Vinblastine Sulfate vs Cyclophosphamide in the Therapy for Lymphoma”

• “Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53”

• “Origin of aneuploidy in relation to disturbances of cell-cycle progression. I. Effects of vinblastine on mouse bone marrow cells”

Not for human therapeutic use or for medicinal purposes. For research applications only.