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Vinblastine Sulfate

SKU
V-1053
  • CAS:143-67-9
  • Formula:C46H58N4O9 • H2SO4
  • MW:909.1
  • Appearance:White to light yellow crystalline powder
  • Purity:≥98% by HPLC

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SDS
CofA
Product Name Qty
Vinblastine Sulfate
5 mg
$68.34
Vinblastine Sulfate
25 mg
$250.59
Vinblastine Sulfate
10 mg
$108.21
Vinblastine Sulfate
50 mg
$427.15
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Description

Vinblastine sulfate is a plant alkaloid, arresting the cell cycle in the G2/M phase by blocking mitotic spindle formation. It suppresses normal microtubule assembly and causes abnormal tubulin polymerization. It also inhibits binding of tubulin to microtubule proteins.

The plant alkaloid is related to the apoptosis pathway. It renders Raf-1 activation, phosphorylation of Bcl-2 family proteins, and induction of p53 expression. Apoptosis in human acute promyelocytic leukemia cells (APL) is induced by vinblastine sulfate because it inhibits nuclear factor kappa B (NFκB) expression and suppresses NFκB-DNA binding activity. Also, Induction of c-Jun N-terminal kinase (JNK) activation causes apoptosis through caspase-dependent pathway.

 

Applications

• Cell cycle blocker

• Apoptosis inducer

• Chemotherapeutic agent

• Neurofibrillary tangles and neuronal degeneration inducer

 

References

• “Neurofibrillary tangles induced by vincristine and vinblastine sulfate in central and peripheral neurons in vitro”

• “Vinblastine Sulfate vs Cyclophosphamide in the Therapy for Lymphoma”

• “Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53”

• “Origin of aneuploidy in relation to disturbances of cell-cycle progression. I. Effects of vinblastine on mouse bone marrow cells”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
VLB sulfate; Vincaleukoblastine; Vinblastine sulphate; VLB monosulfate; Vincaleukoblastine sulfate; Vinblastine 5; Vinblastine Sulphate
SKU
V-1053
CAS #
143-67-9
Chemical Name
methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.01
Chemical Formula
C46H58N4O9 • H2SO4
Molecular Weight
909.1
Appearance
White to light yellow crystalline powder
Purity
≥98% by HPLC
Solubility
Soluble in DMSO, methanol or water (25 mg/mL)
Storage Temp
-20°C
THERAPEUTIC AREA
Chemotherapeutics, Oncology
USE
G2/M phase cell cycle blocker and apoptosis inducer
Merck Index
13.10044.2001
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
Certificate of Analysis 1
V-1053_V-1053,_C1259.pdf
Certificate of Analysis 2
V-1053_V-1053,_Vinblastine_sulfate,_A9836.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
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