Vincristine Sulfate

SKU
V-1055
  • CAS:2068-78-2
  • Formula:C46H56N4O10H2SO4
  • MW:923.1
  • Appearance:White to off-white solid
  • Purity:≥98%

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Product Name Qty
Vincristine Sulfate
1 mg
$39.86
Vincristine Sulfate
5 mg
$119.60
Vincristine Sulfate
25 mg
$484.10

Description

Vincristine sulfate is a Vinca alkaloid. It blocks mitotic spindle formation in the G2/M phase of the cell cycle. The alkaloid depolymerizes microtubules and interferes binding of tubulin to microtubule proteins. With this antitumor property, it is used for treatment of various cancers such as leukemia, malignant lymphoma, and Hodgkin's disease.

It triggers Raf-1 activation, phosphorylation of Bcl-2 family and induction of p53 expression and downregulates HIF-1a expression.

In addition, it has been reported that vincristine sulfate is a potent neurotoxin and it aroused seizures, mental changes, orthostatic hypotension, inappropriate secretion of antidiuretic hormone, and potentiation of preexisting neurological disease.

 

Applications

• Apoptosis inducer

• Chemotherapeutic agent

 

References

“Niosome Encapsulated of Vincristine Sulfate: Improved Anticancer Activity with Reduced Toxicity in Mice”

“Vincristine Neurotoxicity”

“Vincristine Sulfate in the Treatment of Neuroblastoma in Children”

“Microtubule-active Drugs Taxol, Vinblastine, and Nocodazole Increase the Levels of Transcriptionally Active p53”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Onkovin; VCR sulfate; Vincristine sulphate; Kyocristine; Vincrisul; Vincrex; 22-oxovincaleukoblastine sulfate; Vincasar PFS
SKU
V-1055
CAS #
2068-78-2
Chemical Name
methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.01
Chemical Formula
C46H56N4O10H2SO4
Molecular Weight
923.1
Appearance
White to off-white solid
Purity
≥98%
Solubility
Soluble in water (25 mg/mL) or methanol
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Apoptosis inducing anticancer agent
Merck Index
Merck Index: 13.10048.2001
MDL NUMBER
MFCD08706469
CHEMACX
X1008852-7
INCHI
InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
SMILES
CC[C@@]1(C[C@@H]2C[C@@](c3c(c4ccccc4[nH]3)CC[N@@](C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C=O)C(=O)OC)O.OS(=O)(=O)O
RTECS
OH6340000
UN #'S
UN 1544
PACKING GROUP
II
Handling
Protect from light and moisture
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
Handling Protect from light and moisture
UN #'S UN 1544
Packing Group II
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