Vincristine Sulfate

SKU

V-1055

CAS:2068-78-2
Formula:C₄₆H₅₆N₄O₁₀H₂S_O₄
MW:923.1
Appearance:White to off-white solid
Purity:≥98%

SDS

CofA

Product Name	Qty
Vincristine Sulfate 1 mg $39.86
Vincristine Sulfate 5 mg $119.60
Vincristine Sulfate 25 mg $484.10

Details

Description

Vincristine sulfate is a Vinca alkaloid. It blocks mitotic spindle formation in the G2/M phase of the cell cycle. The alkaloid depolymerizes microtubules and interferes binding of tubulin to microtubule proteins. With this antitumor property, it is used for treatment of various cancers such as leukemia, malignant lymphoma, and Hodgkin's disease.

It triggers Raf-1 activation, phosphorylation of Bcl-2 family and induction of p53 expression and downregulates HIF-1a expression.

In addition, it has been reported that vincristine sulfate is a potent neurotoxin and it aroused seizures, mental changes, orthostatic hypotension, inappropriate secretion of antidiuretic hormone, and potentiation of preexisting neurological disease.

Applications

• Apoptosis inducer

• Chemotherapeutic agent

References

• “Niosome Encapsulated of Vincristine Sulfate: Improved Anticancer Activity with Reduced Toxicity in Mice”

• “Vincristine Neurotoxicity”

• “Vincristine Sulfate in the Treatment of Neuroblastoma in Children”

• “Microtubule-active Drugs Taxol, Vinblastine, and Nocodazole Increase the Levels of Transcriptionally Active p53”

Not for human therapeutic use or for medicinal purposes. For research applications only.

Specifications

More Information

Alternate Name/Synonyms

Onkovin; VCR sulfate; Vincristine sulphate; Kyocristine; Vincrisul; Vincrex; 22-oxovincaleukoblastine sulfate; Vincasar PFS

SKU

V-1055

CAS #

2068-78-2

Chemical Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.01

Chemical Formula

C₄₆H₅₆N₄O₁₀H₂S_O₄

Molecular Weight

923.1

Appearance

White to off-white solid

Purity

≥98%

Solubility

Soluble in water (25 mg/mL) or methanol

Storage Temp

-20°C

THERAPEUTIC AREA

Oncological Disorders

USE

Apoptosis inducing anticancer agent

Merck Index

Merck Index: 13.10048.2001

MDL NUMBER

MFCD08706469

CHEMACX

X1008852-7

INCHI

InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

SMILES

CC[C@@]1(C[C@@H]2C[C@@](c3c(c4ccccc4[nH]3)CC[N@@](C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)OC)O)OC(=O)C)CC)C=O)C(=O)OC)O.OS(=O)(=O)O

RTECS

OH6340000

UN #'S

UN 1544

PACKING GROUP

Handling

Protect from light and moisture

Certificate of Analysis 1

V-1055, G1302.pdf

Certificate of Analysis 2

V-1055, A9054.pdf

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