Description

Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Virginiamycin B acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Virginiamycin B is a macrolide antibiotic. It inhibits the growth of Clostridium, Peptostreptococcus, and Propionibacterium bacterial species (MIC90s = 2, 0.5, and 8 μg/ml, respectively). It is inhibited its antibiotic function by erythromycin ribosome methylation genes interfering with Virginiamycin B binding.

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Application

• Use as an antibiotic

• Inhibition of protein synthesis

Reference

• “Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants” 

• Inhibition of protein synthesis by streptogramins and related antibiotics

• Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms

Not for human therapeutic use or for medicinal purposes. For research applications only