Virginiamycin B

SKU
V-2499
  • CAS:3131-03-1
  • Formula:C45H54N8O10
  • MW:867.0 Da
  • Appearance:White solid
  • Purity:>99% by HPLC
Product Name Qty
Virginiamycin B
5 mg
$425.00

Description

Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Virginiamycin B acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Virginiamycin B is a macrolide antibiotic. It inhibits the growth of Clostridium, Peptostreptococcus, and Propionibacterium bacterial species (MIC90s = 2, 0.5, and 8 μg/ml, respectively). It is inhibited its antibiotic function by erythromycin ribosome methylation genes interfering with Virginiamycin B binding.

Inquire for pricing on quantities >25 mg. 

 

Application

• Use as an antibiotic

• Inhibition of protein synthesis

 

Reference

• “Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants” 

• Inhibition of protein synthesis by streptogramins and related antibiotics

• Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms

 

Not for human therapeutic use or for medicinal purposes. For research applications only


More Information
Alternate Name/Synonyms
Ostreogrycin B; Pristinamycin IA; Streptogramin B; Syncothrecin B1; Synergistin B; Vernamycin B alpha; Virginiamycin IA
SKU
V-2499
CAS #
3131-03-1
Chemical Name
N-[3-[[4-(dimethylamino)phenyl]methyl]-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide
Chemical Formula
C45H54N8O10
Molecular Weight
867.0 Da
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF, and DMSO.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious diseases
USE
Antibiotic, protein synthesis inhibitor
INCHI
InChI=1S/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)/t26?,31?,32?,33?,34-,36?,37?/m0/s1
SMILES
CCC1C(=O)N2CCCC2C(=O)N([C@H](C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)c4c(cccn4)O)C)c5ccccc5)Cc6ccc(cc6)N(C)C)C
Certificate of Analysis 1
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