Withaferin A, WFA

SKU
W-1042
  • CAS:5119-48-2
  • Formula:C28H38O6
  • MW:470.6
  • Appearance:White to off-white Solid
  • Purity:98% (HPLC)
Product Name Qty
Withaferin A
5 mg
$279.18
Withaferin A
10 mg
$603.04
Withaferin A
1 mg
$88.22

Withaferin A is cell permeable and potent angiogenesis inhibitor from the family of withanolides. Withaferin A inhibits endothelial cells (HUVEC) sproutingin vitro (IC50=12nM) andin vivo. Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Our docking results obtained substantiate the hypothesis that Wthaferin Ahas the potential to inhibit the association of chaperone (Hsp90) to its co-chaperone (Cdc37) by disrupting the stability of attachment of Hsp90 to Cdc37. Conclusively our results strongly suggest that withaferin A is a potent anticancer agent as ascertained by its potent Hsp90-client modulating capability. Gliosis is a biological process that occurs during injury repair in the central nervous system and is characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic protein (GFAP) and vimentinWithaferin Abinds to and down-regulates soluble vimentin and GFAP expression to cause cell cycle G/G arrest.Finally, Withaferin A displays neuronal regenerative properties.

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More Information
Alternate Name/Synonyms
[5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide], WA, WFA
SKU
W-1042
CAS #
5119-48-2
Chemical Name
[5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide]
Chemical Formula
C28H38O6
Molecular Weight
470.6
Appearance
White to off-white Solid
Purity
98% (HPLC)
Solubility
DMSO (20 mg/ml), methanol (10 mg/ml),100% ethanol
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An antiangiogenesis compound and poteasome inhibitor.Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties
Merck Index
Merck: 14:10048
MDL NUMBER
MFCD10687098
CHEMACX
X1710961-6
INCHI
InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
SMILES
CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO
RTECS
KE7288500
Handling
Protect from LightHARMFUL.Maybe Carcinogenic and Mutagenic.
Certificate of Analysis 1
Handling Protect from LightHARMFUL.Maybe Carcinogenic and Mutagenic.
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