SDS
CofA
A Tankyrase (TNKS) inhibitor (IC= 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation ofcatenin degradation and stabilization of axin. Inhibits proliferation of the-catenin-dependent colon carcinoma cell line DLD-1.
More Information
Alternate Name/Synonyms
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
SKU
X-2484
CAS #
284028-89-3
Chemical Name
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
Chemical Formula
C14H11F3N2OS
Molecular Weight
312.31
Appearance
White Solid
Purity
98% by HPLC
Solubility
DMSO (50 mM)
Melting Point
207.14 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A potent inhibitor of beta-catenin, TNKS1, and TNKS2.XAV939 inhibits colony formation of APC-deficient colorectal cancer cells
MDL NUMBER
MFCD16879017
CHEMACX
X1833197-6
INCHI
InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
SMILES
c1cc(ccc1c2[nH]c(=O)c3c(n2)CCSC3)C(F)(F)F
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 2811
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
| Handling | Protect from air and light |
|---|---|
| UN #'S | UN 2811 |
| Packing Group | III |
