Xestospongin C

SKU
X-1009
  • CAS:88903-69-9
  • Formula:C28H50N2O2
  • MW:446.7
  • Appearance:White to Off-White Solid (may appears as clear film on vial)
  • Purity:90%
Product Name Qty
Xestospongin C
50 ug
$386.41
Xestospongin C
100 ug
$737.08
A reversible and membrane-permeable blocker of IP3-mediated Ca2+ release. It does not interact with the IP3-binding site.Also reported to block the increase in intracellular calcium in vascular smooth muscle cells completely at a concentration of 25 mM. Xestospongin C also inhibits the sarcoplasmic reticulum Ca2+ ATPase pump at concentrations of 700nM. This product is freely soluble in organic solvents such as chloroform, ethyl acetate, and methyl acetate and slightly soluble in DMSO and H2O.Serotonin modulates the population activity profile of olfactory bulb external tufted cells.Mitochondrial Reactive Oxygen Species Are Activated by mGluR5 through IP3 and Activate ERK and PKA to Increase Excitability of Amygdala Neurons and Pain Behaviorf.Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress andCell Death.Glucose and Endoplasmic Reticulum Calcium Channels Regulate HIF. Presenilin in PancreaticCells.
More Information
Alternate Name/Synonyms
XeC, Araguspongine E
SKU
X-1009
CAS #
88903-69-9
Chemical Name
1R- (1R*,4aR*,11R*,12aS*,13S*,16aS*,23R*,24aS*)]- eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H- [1,11]dioxacycloeicosino[2,3-b:12,13-b1]dipyridine
Chemical Formula
C28H50N2O2
Molecular Weight
446.7
Appearance
White to Off-White Solid (may appears as clear film on vial)
Purity
90%
Solubility
Soluble in DMSO or 0.1 N NaOH.
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Not Available
MDL NUMBER
MFCD01862629
CHEMACX
X1277713-6
INCHI
InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m0/s1
SMILES
C1CCC[C@H]2CCN3CCC[C@@H]([C@H]3O2)CCCCCC[C@H]4CCN5CCC[C@H]([C@H]5O4)CC1
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial Protect from Light Packaged under inert gas.
Citations
ISLET STUDIES: Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and β-Cell Death Dan S. Luciani, Kamila S. Gwiazda, Ting-Lin B. Yang, Tatyana B. Kalynyak, Yaryna Bychkivska, Matthew H.Z. Frey, Kristin D. Jeffrey, Arthur V. Sampaio, T. Michael Underhill, and James D. Johnson Diabetes, Feb 2009; 58: 422 - 432.
Citations_Hyperlink
http://diabetes.diabetesjournals.org/cgi/reprint/58/2/422
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Store in Tightly Sealed Vial Protect from Light Packaged under inert gas.
UN #'S Not Applicable
Packing Group Not Applicable
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