• CAS:170632-47-0
  • Formula:C19H16N2O2
  • MW:304.4
  • Appearance:Off-White to Yellow Solid
  • Purity:98%
Product Name Qty
1 mg
5 mg
25 mg

A direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide.Involvement of P2X7 Receptors A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1,

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Alternate Name/Synonyms
3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole
Chemical Name
3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole
Chemical Formula
Molecular Weight
Off-White to Yellow Solid
Melting Point
110-113 °C
Storage Temp
Oncological Disorders
YC-1 is a potential anticancer drug targeting hypoxia-inducible factor 1
Peptide sequence
Not Applicable
UN #'S
Not Applicable
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Not Applicable
Store in Tightly Sealed Vial
POSTER PRESENTATIONS - RADIOSENSITIZATION AND RADIOPROTECTION: Abstract 2514: Radiation-induced HIF-1α prevents apoptosis through reduction of ROS productions after irradiation in glioblastoma Katsuyuki Shirai, Kamalakannan Palanichamy, Krishnan Thirumoorthy, Disha Patel, Nicolaus Gordon, and Arnab Chakravarti Cancer Res., Apr 2011; 71: 2514.
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HandlingStore in Tightly Sealed Vial
UN #'SNot Applicable
Packing GroupNot Applicable
CitationsInvolvement of P2X7 receptors in the hypoxia-induced death of rat retinal neurons
Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer
Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1
YC-1 induces S cell cycle arrest and apoptosis by activating checkpoint kinases
A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia
Abstract 2514: Radiation-induced HIF-1α prevents apoptosis through reduction of ROS productions after irradiation in glioblastoma
Trauma-hemorrhage and hypoxia differentially influence kupffer cell phagocytic capacity: role of hypoxia-inducible-factor-1alpha and phosphoinositide 3-kinase/Akt activation
Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading
PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}
Radiation-induced HIF-1α Upregulates Glycolysis and Exhibits Radioresistance in Glioblastoma
Using YC-1 to overcome the radioresistance of hypoxic cancer cells
Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1
Carbon monoxide ameliorates renal cold ischemia-reperfusion injury with an upregulation of vascular endothelial growth factor by activation of hypoxia-inducible factor
Hypoxia Inducible Factor-1α Regulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrin α 4
Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis
Estrogen suppresses cardiac IL-6 after trauma-hemorrhage via a hypoxia-inducible factor 1 alpha-mediated pathway
A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent
Potent ameliorating effect of Hypoxia-inducible factor 1α (HIF-1α) antagonist YC-1 on combined allergic rhinitis and asthma syndrome (CARAS) in Rats
Comparative relaxant effects of YC-1 and DETA/NO on spontaneous contractions and the levels of cGMP of isolated pregnant rat myometrium
Hypoxia enhances the angiogenic potential of human dental pulp cells
Nuclear factor kappa-B signaling is integral to ocular neovascularization in ischemia-independent microenvironment
The nexus between VEGF and NFκB orchestrates a hypoxia-independent neovasculogenesis
Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy
Oxygen sensing mesenchymal progenitors promote neo-vasculogenesis in a humanized mouse model in vivo
Activation of the AMP-activated protein kinase (AMPK) by nitrated lipids in endothelial cells
Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy
Antiangiogenic role of miR-361 in human umbilical vein endothelial cells: functional interaction with the peptide somatostatin
Hypoxia effects on proangiogenic factors in human umbilical vein endothelial cells: functional role of the peptide somatostatin
Nitric oxide induces endometrial secretion at implantation time
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits the spontaneous contractions of isolated pregnant rat myometrium
Lipopolysaccharide induces hypoxia-inducible factor-1 alpha mRNA expression and activation via NADPH oxidase and Sp1-dependent pathway in BV2 murine microglial cells
Hypoxia induces glucose uptake and metabolism of adipose‑derived stem cells
Coculture of stem cells from apical papilla and human umbilical vein endothelial cell under hypoxia increases the formation of three-dimensional vessel-like structures in vitro
GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance
Potencial angiogênico de células pulpares humanas em hipóxia
放射線治療感受性と HIF-1 及び Notch pathway の関連性の検討
YC-1: A Potential Anticancer Drug Targeting Hypoxia-Inducible Factor
Effect of hypothyroidism on the NO/cGMP pathway of corpus cavernosum in rabbits
Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4 -injured rat liver model via increased autophagic mechanism
Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression†
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