Z-VAD-FMK Caspase-Family Inhibitor

SKU
C-2257
  • CAS:187389-52-2
  • Formula:C22H30N3O7F
  • MW:467.5
  • Appearance:Liquid
  • Purity:Single spot by TLC
Product Name Qty
Z-VAD-FMK Caspase-Family Inhibitor
20 ug
$149.00

A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used in both in vitro and in vivo studies.  (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

More Information
Alternate Name/Synonyms
Z-VAD-FMK, Caspase-Family Inhibitor (fluoromethylketone)
SKU
C-2257
CAS #
187389-52-2
Chemical Name
METHYL-(3S)-5-FLUORO-3-[[(2S)-2-[[(2S)-3-METHYL-2-(PHENYLMETHOXYCARBONYLAMINO)BUTANOYL]AMINO]PROPANOYL]AMINO]-4-OXOPENTANOATE
Chemical Formula
C22H30N3O7F
Molecular Weight
467.5
Appearance
Liquid
Purity
Single spot by TLC
Storage Temp
-20°C
USE
Z-VAD(OMe)-FMK is an irreversible and cell permeable broad-spectrum Caspase Inhibitor
MDL NUMBER
MFCD02684037
CHEMACX
X1277750-9
INCHI
InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
SMILES
C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCc1ccccc1
Peptide sequence
Z-VAL-ALA-ASP-(OME)-FMK
Handling
Protect from light and moisture
HandlingProtect from light and moisture
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