Zebularine

SKU
Z-2609
  • CAS:3690-10-6
  • Formula:C9H12N2O5
  • MW:228.2
  • Appearance:white powder
  • Purity:>98% (HPLC)
Product Name Qty
Zebularine
5 mg
$56.46
Zebularine
10 mg
$79.04
Zebularine
25 mg
$220.18
Zebularine
50 mg
$316.16

DNA methyltransferase inhibitor which binds covalently to methyltransferases. Re-activates silenced E-cadherin expression in EBV-harboring Burkitt’s lymphoma Akata cells. Delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Potentiates differentiation of mesenchymal stem cells into cardiomyocytes. Inhibits cytidine deaminase (Ki ~ 2 μM). Active in vivo.

References:

1. L Zhou et al. J. Mol. Biol. 2002 321:591

2. SP Rao et al. Mol. Cancer 2007 6:3

3. M Chen et al. Mol. Cancer Ther. 2012 11:370

4. N Naeem et al. Cardiovasc. Ther. 2013 31:201

5. J Laliberte et al. Cancer Chemother. Pharmacol. 1992 30:7

More Information
Alternate Name/Synonyms
1H-b-D-ribofuranosyl-2-pyrimidinone,
SKU
Z-2609
CAS #
3690-10-6
Chemical Formula
C9H12N2O5
Molecular Weight
228.2
Appearance
white powder
Purity
>98% (HPLC)
Solubility
DMSO (20 mg/ml); or water (20 mg/ml)
Storage Temp
-20°C
Hazard Image
Yes
To Top