ZM 336372

SKU
Z-1021
  • CAS:208260-29-1
  • Formula:C23H23N3O3
  • MW:389.4
  • Appearance:Off White Solid
  • Purity:95%
Product Name Qty
ZM 336372
5 mg
$153.79
ZM 336372
25 mg
$620.78
A potent and specific inhibitor of the protein kinase c-Raf (IC = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 M) with the exception of SAPK2a/p38a (IC50 = 2 M) and SAPK2b/p38b2 (IC = 2 M). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
More Information
Alternate Name/Synonyms
N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
SKU
Z-1021
CAS #
208260-29-1
Chemical Name
N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
Chemical Formula
C23H23N3O3
Molecular Weight
389.4
Appearance
Off White Solid
Purity
95%
Solubility
Soluble in DMSO (200mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell
MDL NUMBER
MFCD02683971
CHEMACX
X1461526-0
INCHI
InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
SMILES
Cc1ccc(cc1NC(=O)c2ccc(cc2)O)NC(=O)c3cccc(c3)N(C)C
Handling
Protect from Light Packaged under inert gas.
Handling Protect from Light Packaged under inert gas.
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