Zotarolimus

SKU
Z-2597
  • CAS:221877-54-9
  • Formula:C52H79N5O12
  • MW:966.2
  • Appearance:White solid
  • Purity:>95% by HPLC
Product Name Qty
Zotarolimus
1 mg
$117.33
Zotarolimus
5 mg
$411.20
Zotarolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by preparation of the 42-triflate ester, followed by displacement with tetrazole and purification of the two isomeric products. This structural change affords a less bioavailable product, a preferred profile for some applications. Like all tacrolimus analogues, zotarolimus binds to a receptor protein (FKBP12). The complex then binds to mTOR preventing it from interacting with target proteins. Zotarolimus is extensively cited in the literature with over 200 citations.
More Information
SKU
Z-2597
CAS #
221877-54-9
Chemical Name
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-DIHYDROXY-19,30-DIMETHOXY-12-((2R)-1-[(1S,3R,4S)-3-METHOXY-4-(1H-TETRAZOL-1-YL)CYCLOHEXYL]-2-PROPANYL)-15,17,21,23,29,35-HEXAMETHYL-11, 36-DIOXA-4-AZATRICYCLO[30.3.1.04,9]HEXATRIACONTA-16,24
Chemical Formula
C52H79N5O12
Molecular Weight
966.2
Appearance
White solid
Purity
>95% by HPLC
Melting Point
100-105°C
Storage Temp
4°C
THERAPEUTIC AREA
Vascular Disorders
USE
Zotarolimus is useful in the treatment of restenosis
INCHI
InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1
SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@@H]([C@@H](C4)OC)n5cnnn5)C)/C)O)OC)C)C)/C)OC
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