5-Methylcytidine

SKU
M-1106
  • CAS:2140-61-6
  • Formula:C10H15N3O5
  • MW:257.2 Da
  • Appearance:White to off-white powder
  • Purity:≥99%

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Product Name Qty
5-Methylcytidine
1 g
$455.17

5-Methylcytidine is a modified nucleoside derived from 5-methylcytosineIt has been used in epigenetics research, especially in studies involving DNA methylation processes including genomic imprinting and the control of gene expression and differentiation.

The presence of 5-methylcytidine (m5C) in tRNA and rRNA molecules of a wide variety of organisms was first observed more than 40 years ago. Recent studies in eukaryotes have shown that mRNA modifications such as RNA-editing (conversion of an adenosine base to inosine), N6-adenine methylation (m6A), and 5-methylcytidine (m5C) can change the coding sequence, alter splicing patterns, or change RNA stability. 5-methylcytidine (m5C) is a modification that occurs both on DNA and RNA. In eukaryotes, this DNA modification has been extensively studied over the past years, and has been found to play a crucial role in genomic imprinting, X-chromosome inactivation, and suppression of repetitive elements.

More Information
Alternate Name/Synonyms
5-methyl-cytidine; 5-Methyl-D-cytidine
SKU
M-1106
CAS #
2140-61-6
Chemical Name
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one
Chemical Formula
C10H15N3O5
Molecular Weight
257.2 Da
Appearance
White to off-white powder
Purity
≥99%
Solubility
May be dissolved in water (25 mg/mL)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
5-Methylcytidine has been found in mouse liver emulsion and has been shown to inhibit the growth of spontaneous tumors originating in the mammary gland. It is a nucleosides that, using liquid chromatography and ion trap mass spectrometry coupling, can be used as biomedical marker. It is used in studies of DNA methylation processes (epigenetics).
Merck Index
Merck Index: 13. .2001
MDL NUMBER
MFCD00006548
CHEMACX
X1014453-1
INCHI
InChI=1S/C10H15N3O5/c1-4-2-13(10(17)12-8(4)11)9-7(16)6(15)5(3-14)18-9/h2,5-7,9,14-16H,3H2,1H3,(H2,11,12,17)/t5-,6-,7-,9-/m1/s1
SMILES
Cc1cn(c(=O)nc1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
Peptide sequence
Not Applicable
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
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