A83-01

SKU
A-1764
  • CAS:909910-43-6
  • Formula:C25H19N5S
  • MW:421.52
  • Appearance:Pale Yellow Solid
  • Purity:98% by HPLC

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Product Name Qty
A83-01
1 mg
$35.00
A83-01
5 mg
$65.00
A83-01
25 mg
$235.00

A selective inhibitor of TGF-type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-induced epithelial-to-mesenchymal transition. Helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs)

More Information
Alternate Name/Synonyms
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
SKU
A-1764
CAS #
909910-43-6
Chemical Name
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Chemical Formula
C25H19N5S
Molecular Weight
421.52
Appearance
Pale Yellow Solid
Purity
98% by HPLC
Solubility
DMSO (50 mM)
Storage Temp
Store at -20°C
THERAPEUTIC AREA
Oncological Disorders
USE
An inhibitor of TGF-β type I receptor ALK5 kinase signaling facilitates tumor growth and metastasis in Metastatic Cancer
MDL NUMBER
MFCD08705403
CHEMACX
X1543876-9
INCHI
InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
SMILES
Cc1cccc(n1)c2c(cn(n2)C(=S)Nc3ccccc3)c4ccnc5c4cccc5
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
Certificate of Analysis 1
/media/upload/pdf/A-1764, E1405.pdf
GHS PICTOGRAMS
Handling Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
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