- MW:421.52 Da
- Appearance:Light yellow powder
- Purity:≥98% by HPLC
A83-01 is a selective inhibitor of TGF-type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-induced epithelial-to-mesenchymal transition. Helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs)
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.|