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Amphotericin B

SKU
A-1077
  • CAS:1397-89-3
  • Formula:C47H73NO17
  • MW:924.091 Da
  • Appearance:Yellow or orange powder
  • Purity:≥750 µg/mg (Assay)

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CofA
Product Name Qty
Amphotericin B
1 g
$96.82
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Description

Amphotericin B is a polyene anti-fungal antibiotic from Streptomyces nodosus that non-specifically induces loss of low molecular weight substances from cells. It binds to sterols and disrupts osmotic integrity of fungal membranes, forming pores which leads to the leakage of essential ions, causing cell death. 

 

Applications

• Amphotericin B is used to control contamination from fungi, viruses, and protozoa.

• Treatment of serious, life-threatening fungal infections. Not to be used for treatment of minor fungal infections.

 

Specifications

• Beilstein Registry Number: 78342

• EC Number: 215-742-2

 

Additional Reading from AG Scientific

• Amphotericin B for Viral Research

• Polyene Macrolide Antibiotics

• A Guide to the 8 Most Common Classes of Antibiotics

• What Can Be Done to Fight Antibiotic Resistance?

• Download Brochure: Antibiotics

 

Reference

• "Repurposing Ivermectin to inhibit the activity of SARS CoV2 helicase: possible implications for COVID 19 therapeutics"

• "Virtual screening of an FDA approved drugs database on two COVID-19 coronavirus proteins"

• "Combined prophylactic and therapeutic use maximize hydroxychloroquine anti-SARS-CoV-2 effects in vitro" 

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Fungizone; Fungilin; Ampho-Moronal; Amfotericina B; Halizon; Amphocin; Ambisome; Amphozone; Fungilin; Abelcet; Abelecet; Ampho-Moronal; Amphotec; Fungisome; Fungisone; Mysteclin-F
SKU
A-1077
CAS #
1397-89-3
Chemical Name
(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,
Chemical Formula
C47H73NO17
Molecular Weight
924.091 Da
Appearance
Yellow or orange powder
Purity
≥750 µg/mg (Assay)
Solubility
DMSO (35 mg/ml), DMF (3 mg/ml), water (no information available)
Storage Temp
+4°C
THERAPEUTIC AREA
Anti-fungal antibiotic
USE
Cell culture antibiotic. For research use only. Not intended for diagnostic or therapeutic use. / One of the main uses of amphotericin B is treating a wide range of systemic fungal infections. Due to its extensive side effects, it is often reserved for severe infections in critically ill, or immunocompromised patients. It is considered first line therapy for invasive mucormycosis infections, cryptococcal meningitis, and certain aspergillus and candidal infections.
Merck Index
13.590.2001
MDL NUMBER
MFCD00877763
CHEMACX
X1004282-9
PubChecm ID
5280965
INCHI
InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
SMILES
CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
RTECS
BU2625000
Handling
Protect from light and moisture. Packaged under inert gas. The pharmacological and toxicological properties of this product have not been fully investigated. Use caution when handling. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Certificate of Analysis 1
A-1077, L1146.pdf
Certificate of Analysis 2
A-1077, K1432A.pdf
Certificate of Analysis 3
A-1077, J1012C.pdf
GHS PICTOGRAMS
Handling Protect from light and moisture. Packaged under inert gas. The pharmacological and toxicological properties of this product have not been fully investigated. Use caution when handling. Do not use this compound if you are not fully trained or are unaware of the hazards involved. Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Citations N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents
Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis
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