Anisomycin (Flagecidin)
SKU
A-1049
- CAS:22862-76-6
- Formula:C14H19NO4
- MW:265.31 Da
- Appearance:White crystalline powder
- Purity:≥98% (HPLC)
SDS
CofA
Description
Anisomycin is isolated from several species of Streptomyces griseolus. It interferes with the synthesis of protein and DNA by inhibiting the peptidyl transferase of the 80S ribosomal system. Anisomycin is also a JNK agonist, MAP kinases activator, anti-protozoal agent, and an apoptosis promoter in promyelocytic leukemia cells, Jurkat cells, ventricular monocytes, and colon adenocarcinoma cells.
Applications
• antibacterial, for its ability to reduce growth and block the diffusion of bacteria
• antiprotozoal, for its effectiveness in the destruction of protozoa
• Inhibitor of nucleic acid and protein synthesis
More Information
Alternate Name/Synonyms
Flagecidin; (-)-Anisomycin; Anhydroscopin A; NSC 76712; (2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate; (2R,3S,4S)-2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate; 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate
SKU
A-1049
CAS #
22862-76-6
Chemical Name
[(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate
Chemical Formula
C14H19NO4
Molecular Weight
265.31 Da
Appearance
White crystalline powder
Purity
≥98% (HPLC)
Solubility
Soluble in DMSO
Melting Point
139-142°C
Preparation
N/A
Storage Temp
Store desiccated at +4° C
THERAPEUTIC AREA
Psychological Disorders, Infectious Diseases
USE
For research use only. Not for human or drug use. Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is also mentioned as a potential psychiatric drug, as it may inhibit the consolidation of new context-specific long-term memories, as well as long time consolidated memories rendered labile through reactivation.
Merck Index
13.673.2001
MDL NUMBER
MFCD00077650
CHEMACX
X1000859-4
INCHI
InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
SMILES
CC(=O)O[C@H]1[C@@H](CN[C@H]1Cc2ccc(cc2)OC)O
RTECS
BZ9800000
UN #'S
UN 2811, 2941.90.1050
PACKING GROUP
III
HAZARD CLASS
6.1 Toxic
Handling
Protect from light and moisture. Warning: very Toxic
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilatio
Special Shipping
Yes
Citations
RESEARCH:
Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans
Hisayuki Amano and Ichiro N. Maruyama
Learn. Mem., Sep 2011; 18: 654 - 665.
Citations_Hyperlink
http://learnmem.cshlp.org/cgi/reprint/18/10/654
Cat. #
MST-A1215
MSDS Available?
Yes
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Protect from light and moisture. Warning: very Toxic Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilatio |
| UN #'S | UN 2811, 2941.90.1050 |
| Packing Group | III |
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