Antipain Dihydrochloride

SKU
A-1448
  • CAS:37682-72-7
  • Formula:C27H44N10O6 • 2HCl
  • MW:677.7
  • Appearance:White to off-white powder

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Product Name Qty
Antipain Dihydrochloride
25 mg
$145.00
Antipain Dihydrochloride
10 mg
$74.99
Antipain Dihydrochloride
100 mg
$550.00
Antipain Dihydrochloride
5 mg
$39.99

Inhibits papain and trypsin and to a small extent plasmin. Antipain is more specific for papain and trypsin than is leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.

More Information
Alternate Name/Synonyms
Antipain 2HCl, N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride, [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal 2HCl
SKU
A-1448
CAS #
37682-72-7
Chemical Name
2-[[(2S)-5-CARBAMIMIDAMIDO-1-[[(2S)-1-[(5-CARBAMIMIDAMIDO-1-OXOPENTAN-2-YL)AMINO]-3-METHYL-1-OXOBUTAN-2-YL]AMINO]-1-OXOPENTAN-2-YL]CARBAMOYLAMINO]-3-PHENYLPROPANOIC ACID DIHYDROCHLORIDE
Chemical Formula
C27H44N10O6 • 2HCl
Molecular Weight
677.7
Appearance
White to off-white powder
Solubility
Soluble in water, methanol, 100% ethanol or acetonitrile
Storage Temp
-20°C
USE
Antipain dihydrochloride is a reversible protease inhibitor produced by actinomycetes
MDL NUMBER
MFCD00135957
CHEMACX
X1009642-5
INCHI
InChI=1S/C27H44N10O6.2ClH/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43);2*1H/t18?,19-,20?,21-;;/m0../s1
SMILES
CC(C)[C@@H](C(=O)NC(CCCN=C(N)N)C=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)NC(Cc1ccccc1)C(=O)O.Cl.Cl
Peptide sequence
PHE-ARG-VAL-ARG-CHO 2HCL
RTECS
YV9350800
Handling
Protect from light
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Protect from light
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