Ascomycin, Streptomyces hygroscopicus var ascomyceticus
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Ascomycin is an ethyl analog of FK506 with strong immunosuppressant properties. Acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Ascomycin acts a calcineurin phosphatase inhibitor (CNPI)1.