Ascomycin

SKU
A-1258
  • CAS:11011-38-4
  • Formula:C43H69NO12
  • MW:792.0
  • Appearance:White powder
  • Purity:≥98%

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Product Name Qty
Ascomycin
25 mg
$147.90
Ascomycin
1 mg
$35.70
Ascomycin
5 mg
$61.20

Description

Ascomycin is an analog of FK506 with potent immunosuppressive antibiotic properties. It is an intensive calcium-dependent serine/threonine protein phosphatase inhibitor.

Ascomycin suppresses T-cell proliferation through binding to calcineurin (CaN) and interferes with dephosphorylation of various substrates. The mechanism downregulates production of interleukin 2 (IL2), interleukin 4 (IL4), and the release of cytokines.

It has known anticonvulsant activity in rat models. Because of CaN-mediated regulation of gamma aminobutyric acid (GABA) and glutamate receptor channels, ascomycin is related to neuronal cytoskeleton and dendritic spine morphology and inflammatory responses in gila cells. It blocks signaling pathways in astrocytes and changes the pattern of cytokine and neurotrophin gene expression.

Isolated from Streptomyces hygroscopicus var ascomyceticus.

 

Applications

• Immunosuppressive antibiotic

• Used for inflammatory skin

• Neuronal disease study

 

Specifications

• EC Number: 435-850-5

 

References

“Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants”

“Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Immunomycin, FK 520, FR 520, FR 900520, CTK8E7561
SKU
A-1258
CAS #
11011-38-4
Chemical Name
(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-ethyl-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
Chemical Formula
C43H69NO12
Molecular Weight
792.0
Appearance
White powder
Purity
≥98%
Solubility
Solubility: Soluble in DMSO.
Melting Point
163-164‚°C
Storage Temp
Store in a freezer upon arrival, at -10°C to -25°C
USE
FK520-like, potent immunosuppressant
Handling
This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this material Store at -18 celsius degree.
Certificate of Analysis 1
Certificate of Analysis 2
Handling This product should be handled only by qualified experienced professionals. Wash thoroughly after handling this material Store at -18 celsius degree.
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