Bestatin HCl

SKU
B-1075
  • CAS:65391-42-6
  • Formula:C16H24N2O4 • HCl
  • MW:344.8 Da
  • Appearance:White powder
  • Purity:≥98% (HPLC)

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Product Name Qty
Bestatin HCl
5 mg
$44.00
Bestatin HCl
10 mg
$82.00
Bestatin HCl
25 mg
$198.00
Bestatin HCl
100 mg
$450.00

Description

Bestatin hydrochloride is a metalloprotease inhibitor of aminopeptidase, aminopeptidase B, aminopeptidase M (CD13), and leucine aminopeptidase (LAP3) derived from Streptomyces olivoreticuli. The inhibition of these proteins is due to apoptosis induction in oncogenic cells. Bestatin displays efficacy in anticancer chemotherapeutic, immunomodulatory, and analgesic activities

Applications

• Treatment of acute promyelocytic leukemia
• Intensified the antinociceptive effects of low-dose of NA3
• enhances proliferation of bone marrow macrophage progenitor cells
• Amplifies formation of CFU-GM colonies
• Efficacy in lung cancer treatments

More Information
Alternate Name/Synonyms
Ubenimex hydrochloride
SKU
B-1075
CAS #
65391-42-6
Chemical Name
(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride
Chemical Formula
C16H24N2O4 • HCl
Molecular Weight
344.8 Da
Appearance
White powder
Purity
≥98% (HPLC)
Solubility
Clear to slightly hazy 10mg/ml in water, Up to 20mg/ml in HCI and Up to 5mg/ml in MeOH.
Melting Point
213-215°C
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Oncological disorders
USE
Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.
Merck Index
N/A
MDL NUMBER
MFCD00058004
CHEMACX
X1087674-3
INCHI
InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
SMILES
CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O.Cl
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
Downloads Title
MSDS Documentation
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
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