Beta Lactamase

SKU
L-1163
  • CAS:9073-60-3
  • Appearance:Freeze dried powder

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Starting at $61.41

Product Name Qty
Beta lactamase
1 Vial
$61.41

Description

Beta-lactamases are enzymes produced by bacteria (Also known as Penicillinase) that provide resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics structure. Beta-Lactamase ensures sterility of bacterial infections by eliminating false negatives via the removal of antibiotics in blood samples

These antibiotics all have a common element in their molecular structure: a four-atom ring known as a β-lactam. Through hydrolysis, the lactamase enzyme breaks the β-lactam ring open, deactivating the molecule's antibacterial properties. Beta-lactam antibiotics are typically used to treat a broad spectrum of Gram-positive and Gram-negative bacteria. Beta-lactamases produced by Gram-negative organisms are usually secreted, especially when antibiotics are present in the environment.

 

Applications

Testing sterility of blood cultures - Blood cultures are routinely prepared in order to test for bacterial infection. False negative results might be obtained where the blood sample contains antibiotics. Incorporation of β-Lactamase in the culture medium will overcome this problem when cephalosporins/penicillins are present
Testing for contamination of drugs by antibiotics - US Code of Federal regulations states that “If a reasonable possibility exists that a non-penicillin drug product has been exposed to cross-contamination with penicillin, the non-penicillin drug product shall be tested for the presence of penicillin” (21 CFR 211.176, Penicillin Contamination, FDA, BY-Lines No. 8 November 1977)
Environmental monitoring of antibiotic manufacturing area
Sterility testing of bulk antibiotics as described by US Pharmcopeia (USP) Chapter 71 and EP Section 2.6

 

More Information
Alternate Name/Synonyms
Penicillinase; β-Lactamase I from Bacillus cereus; β-Lactamase II, Cephalosporinase; Penicillin amido-β-lactam hydrolase
SKU
L-1163
CAS #
9073-60-3
Chemical Formula
N/A
Molecular Weight
N/A
Appearance
Freeze dried powder
Purity
N/A
Solubility
Soluble in Water.
Melting Point
N/A
Preparation
Vialed products are stabled as supplied > 2yrs.
Storage Temp
+4°C
THERAPEUTIC AREA
Not Applicable
USE
Beta-lactamases are enzymes produced by bacteria that provide multi-resistance to β-lactam antibiotics such as penicillins, cephalosporins, cephamycins, and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a β-lactam. Through hydrolysis, the lactamase enzyme breaks the β-lactam ring open, deactivating the molecule's antibacterial properties.
Merck Index
N/A
RTECS
N/A
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
Additional Videos
msds 1
/media/upload/pdf/L-1163, Beta-Lactamase, SDS, diamond format.pdf
Certificate of Analysis 1
/media/upload/pdf/L-1163, J1172.pdf
Certificate of Analysis 2
/media/upload/pdf/L-1163, H1198.pdf
Certificate of Analysis 3
/media/upload/pdf/L-1163, G1057.pdf
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
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