Bicyclomycin

SKU
B-2549
  • CAS:38129-37-2
  • Formula:C12H18N2O7
  • MW:302.3 Da
  • Appearance:White solid
  • Purity:>95% by HPLC

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Product Name Qty
Bicyclomycin
1 mg
$300.00
Bicyclomycin
5 mg
$1,100.00

Bicyclomycin (also called Bicozamycin) is a polar metabolite first isolated from Streptomyces sapporonensis in 1972, with activity against Gram negative bacteria. The selective Gram-negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.

 

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More Information
Alternate Name/Synonyms
Bicyclomycin; Bicozamycin; Aizumycin; Bacteron; Bicozamicina; Bicozamycine; Bicozamycinum; Bacfeed
SKU
B-2549
CAS #
38129-37-2
Chemical Name
(1S,6R)-6-hydroxy-5-methylidene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
Chemical Formula
C12H18N2O7
Molecular Weight
302.3 Da
Appearance
White solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol, methanol, DMF, DMSO, and water
Melting Point
255.06 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Antibacterial
USE
Bicyclomycin (Bicozamycin) is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteus. This clinically useful antibiotic is rapidly absorbed in man when given intramuscularly, has low toxicity and has been used to treat diarrhea in humans and bacterial diarrhea in calves and pigs.
MDL NUMBER
MFCD00865145
INCHI
InChI=1S/C12H18N2O7/c1-6-3-4-21-12(7(16)10(2,19)5-15)9(18)13-11(6,20)8(17)14-12/h7,15-16,19-20H,1,3-5H2,2H3,(H,13,18)(H,14,17)/t7-,10+,11-,12+/m1/s1
SMILES
O=C2N[C@]1(OCCC(=C)\[C@]2(O)NC1=O)[C@H](O)[C@](O)(C)CO
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
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