Magnesium (Mg) is a metallic element and one of the most abundant minerals found on Earth. The mineral does not exist naturally on its own, often making up a part of dolomite and magnesite deposits. Magnesium is essential in the sustenance of life and is located within the core structure of chlorophyll, the green pigment that plants use for photosynthesis. Magnesium ionophores are commonly used to measure magnesium concentrations in various applications.
Magnesium Ionophores for Ion Selective Electrodes

Measuring Magnesium
It is sometimes necessary to accurately measure magnesium levels within the manufacturing and pharmaceutical fields as an excess of the metal may lead to adverse health reactions or disastrous results. Magnesium overdose or hypermagnesemia is a rare condition where sufferers have excess levels of magnesium in their blood. This causes a wide range of physical symptoms such as hot flashes, muscle weakness and nausea. However, this is usually a complication resulting from severe conditions such as kidney failure.
Additionally, magnesium levels are closely monitored under certain environments and conditions, such as managing water hardness in treatment plants to ensure that they are of the highest quality for residential and commercial use. Ion-selective electrodes (ISEs), provide an effective means of detecting accurate levels of metal found within a substance. Specially-selected ionophores are applied as chemical agents in the detection of specific elements. Ionophores are lipophilic (fat/oil-soluble) species of chemicals that have the unique function of reversing the binding of ions. Magnesium ionophores I & III are two ionophores for ISEs commonly used across industries. Magnesium ionophore I is a neutral synthetic ionophore used for Mg2+-selective electrodes while Magnesium ionophore III is an effective receptor for Eu3+ and Am3+ cations.
Potential for Nuclear Waste Management
Disposal and storage of nuclear fuel has remained a major challenge in the world. Although nuclear has served as an effective power source in generating electricity and powering industries, its waste is highly radioactive and can remain in unused reactors for thousands of years. Long-term exposure to radiation is known to cause physical problems and is responsible for illnesses such as cancer.
Researchers have experimented with magnesium-selective ISEs as an extraction agent for micro amounts of trivalent americium (Am3+) and europium (Eu3+) through a nitrobenzene medium. This has led researchers to consider the potential use of magnesium ionophores as a means of nuclear waste treatment in the future for environmental sustenance.
Testing Magnesium Levels in Healthcare
Magnesium-selective ISEs enable clinics to effectively analyze blood, serum, plasma and other aqueous samples for ionized magnesium concentrations through chemometric procedures. This enables healthcare professionals to quickly and reliably identify and treat underlying conditions related to magnesium deficiency (hypomagnesium), such as nausea, vomiting, digestive problems and bone density abnormalities.
Traditionally, researchers have found it a challenge to differentiate selectivity between calcium ( Ca2+) and magnesium (Mg2+) cations. However, advancements in science have enabled experts to achieve a discrimination factor of up to 8, through careful selection from among various membrane compositions.