Z-VAD-FMK

SKU
C-1077
  • CAS:187389-52-2
  • Formula:C21H28FN3O7
  • MW:453.5
  • Appearance:Lyophilized solid or wax
  • Purity:>98%

2

2

0

0

Starting at $233.50

Product Name Qty
Z-VAD-FMK
5 mg
$757.47
Z-VAD-FMK
1 mg
$233.50

Description

A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used in both in vitro and in vivo studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Z-VAD-fluoromethylketone, Caspase Family Inhibitor (FMK)
SKU
C-1077
CAS #
187389-52-2
Chemical Name
Z-Val-Ala-Asp-fluoromethylketone
Chemical Formula
C21H28FN3O7
Molecular Weight
453.5
Appearance
Lyophilized solid or wax
Purity
>98%
Solubility
Soluble in DMSO @ 10mg/ml
Storage Temp
-20°C
MDL NUMBER
MFCD03452883
CHEMACX
X1341251-0
INCHI
InChI=1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1
SMILES
C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCc1ccccc1
Handling
Store in Tightly Sealed Vial Allow vial to acclimate to room temp with top tightly sealed. Dissolve only required amount needed, decomposition ofproductpossible once in solution.
Citations
ENZYME CATALYSIS AND REGULATION: Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation J. Michael Elliott, Lionel Rouge, Christian Wiesmann, and Justin M. Scheer J. Biol. Chem., Mar 2009; 284: 6546 - 6553.
Citations_Hyperlink
http://www.jbc.org/cgi/reprint/284/10/6546
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Store in Tightly Sealed Vial Allow vial to acclimate to room temp with top tightly sealed. Dissolve only required amount needed, decomposition ofproductpossible once in solution.
To Top