Caspase-3 Inhibitor, Ac-DMQD-CHO

SKU
C-1121
  • CAS:259199-63-8
  • Formula:C20H31N5O10S
  • MW:533.6 Da
  • Appearance:White lyophilized powder
  • Purity:≥96% (by HPLC)

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Product Name Qty
Caspase Inhibitor (Aldehyde), Ac-DMQD-CHO
1 mg
$80.40
Caspase Inhibitor (Aldehyde), Ac-DMQD-CHO
5 mg
$294.82

Reversible aldehyde inhibitor of caspase-3. High selectivity for caspase-3 over caspase-1, -4, -6, and -7. In combination withcaspase-6 inhibitor Ac-VEID-CHO (# C-1161),dissects the pathway of caspase activation in Fas-stimulated Jurkat cells.

More Information
Alternate Name/Synonyms
Caspase-3 Inhibitor; Ac-DMQD-CHO; Ac-Asp-Met-Gln-Asp-CHO; Ac-DMQD-CHO (trifluoroacetate salt)
SKU
C-1121
CAS #
259199-63-8
Chemical Name
Ac-Asp-Met-Gln-Asp-al
Chemical Formula
C20H31N5O10S
Molecular Weight
533.6 Da
Appearance
White lyophilized powder
Purity
≥96% (by HPLC)
Solubility
Soluble in DMSO (~40 mg/mL)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
Specific inhibitor of caspase-3. Together with the inhibitor CASP-072 this peptide is capable of dissecting the pathway of caspase activation in Fas-stimulated Jurkat cells.
Merck Index
N/A
MDL NUMBER
MFCD01630895
CHEMACX
X1270014-0
INCHI
InChI=1S/C20H31N5O10S/c1-10(27)22-14(8-17(31)32)20(35)25-13(5-6-36-2)19(34)24-12(3-4-15(21)28)18(33)23-11(9-26)7-16(29)30/h9,11-14H,3-8H2,1-2H3,(H2,21,28)(H,22,27)(H,23,33)(H,24,34)(H,25,35)(H,29,30)(H,31,32)/t11-,12-,13-,14-/m0/s1
SMILES
O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C=O)CC(=O)O)CCC(=O)N)CCSC)[C@@H](NC(=O)C)CC(=O)O
Peptide sequence
AC-ASP-MET-GLN-ASP-CHO
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
PROTECT FROM AIR AND LIGHT! Provide appropriate exhaust ventilation at places where dust is formed.
Certificate of Analysis 1
Certificate of Analysis 2
Handling PROTECT FROM AIR AND LIGHT! Provide appropriate exhaust ventilation at places where dust is formed.
UN #'S Not Applicable
Packing Group Not Applicable
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