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Cefsulodin Sodium Salt

SKU
C-1457
  • CAS:52152-93-9
  • Formula:C22H19N4NaO8S2
  • MW:554.53 Da
  • Appearance:White-yellowish crystalline powder
  • Purity:≥98.0% (HPLC)
Product Name Qty
Cefsulodin Sodium Salt
100 mg
$43.13
Cefsulodin Sodium Salt
500 mg
$147.63
Cefsulodin, Sodium Salt
1 g
$199.30
Cefsulodin Sodium Salt
5 g
$775.38
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Description

Cefsulodin Sodium Salt is a third-generation cephalosporin antibiotic used in CIN (Cefsulodin-Irgasan-Novobiocin) Agar. It displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP). Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 on bacterial cell wall mucopeptide synthesis.

 

Applications

• Used for the treatment of surgical infections caused by Pseudomonas aeruginosa
• Component of MI Agar used in water testing as a contamination control that inhibits the growth of bacteria other than E. coli
• Used in Cefsulodin-Irgasan-Novobiocin Agar, a selective media for the isolation of Yersinia enterocolitica.
• Cefsulodin’s longstanding application identifying Yersinia enterocolitica has a powerful new role in genome editing utilizing the CRISPR/Cas9 system

Specifications

• EC Number: 257-692-4

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Cefsulodin; Cefsulodin Monosodium Salt; Pseudomonil; Pyocefal; Monaspor; Pseudocef; Takesulin; Tilmapor
SKU
C-1457
CAS #
52152-93-9
Chemical Name
sodium;(6R,7R)-3-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[[(2R)-2-phenyl-2-sulfonatoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Chemical Formula
C22H19N4NaO8S2
Molecular Weight
554.53 Da
Appearance
White-yellowish crystalline powder
Purity
≥98.0% (HPLC)
Solubility
Freely soluble in water & formamide. Slightly soluble in methanol. Very slightly soluble in ethanol.
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious diseases
USE
Cefsulodin sodium salt hydrate is a third generation β lactam antibiotic and member of the cephems subgroub of antibiotics. The compound displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) crosslinking of peptidoglycan resulting in inhibition of the final transpeptidation step. Through the inability for Cefsulodin sodium salt hydrate to inhibit cefsulodin-resistant mutants of Pseudomonas aeruginosa PAO4089 growth displayed that Cefsulodin sodium salt hydrate may compete with PBP3 in addtion to PBP1A and PBP1B.
MDL NUMBER
MFCD07793338
CHEMACX
X1026792-4
PubChecm ID
656644
INCHI
InChI=1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1
SMILES
C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)S(=O)(=O)[O-])C(=O)[O-])C[N+]4=CC=C(C=C4)C(=O)N.[Na+]
RTECS
UU1785000
Handling
Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation.
msds 1
C-1457, Cefsulodin Sodium Salt, SDS, diamond format.pdf
Certificate of Analysis 1
C-1457, L1469.pdf
Certificate of Analysis 2
C-1457, L1371.pdf
Certificate of Analysis 3
C-1457, K1034Q.pdf
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation.
CitationsSelective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung
Evaluation of PCR-based methods for the identification of enteroaggregative hemorrhagic Escherichia coli in sprouts
Comparison of the Diatheva STEC FLUO with BAX System Kits for Detection of O157:H7 and Non-O157 Shiga Toxin-Producing Escherichia coli (STEC) in Ground Beef and Bean Sprout Samples Using Different Enrichment Protocols
Advances in methods to detect, isolate and quantify foodborne pathogens
Within-Host Fine-Scale Evolutionary Dynamics of Infectious Bacterial Populations
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