Cefsulodin Sodium Salt

SKU

C-1457

CAS:52152-93-9
Formula:C₂₂H₁₉N₄NaO₈S₂
MW:554.53 Da
Appearance:White-yellowish crystalline powder
Purity:≥98.0% (HPLC)

SDS

CofA

Product Name	Qty
Cefsulodin Sodium Salt 100 mg $42.17
Cefsulodin Sodium Salt 500 mg $144.31
Cefsulodin, Sodium Salt 1 g $194.82
Cefsulodin Sodium Salt 5 g $757.94

Details

Description

Cefsulodin Sodium Salt is a third-generation cephalosporin antibiotic used in CIN (Cefsulodin-Irgasan-Novobiocin) Agar. It displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP). Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 on bacterial cell wall mucopeptide synthesis.

Applications:

• Used for the treatment of surgical infections caused by Pseudomonas aeruginosa
• Component of MI Agar used in water testing as a contamination control that inhibits the growth of bacteria other than E. coli
• Used in Cefsulodin-Irgasan-Novobiocin Agar, a selective media for the isolation of Yersinia enterocolitica.
• Cefsulodin’s longstanding application identifying Yersinia enterocolitica has a powerful new role in genome editing utilizing the CRISPR/Cas9 system

Specifications

• EC Number: 257-692-4

Specifications

More Information

Alternate Name/Synonyms

Cefsulodin; Cefsulodin Monosodium Salt; Pseudomonil; Pyocefal; Monaspor; Pseudocef; Takesulin; Tilmapor

SKU

C-1457

CAS #

52152-93-9

Chemical Name

sodium;(6R,7R)-3-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[[(2R)-2-phenyl-2-sulfonatoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Chemical Formula

C₂₂H₁₉N₄NaO₈S₂

Molecular Weight

554.53 Da

Appearance

White-yellowish crystalline powder

Purity

≥98.0% (HPLC)

Solubility

Freely soluble in water & formamide. Slightly soluble in methanol. Very slightly soluble in ethanol.

Melting Point

N/A

Preparation

N/A

Storage Temp

-20°C

THERAPEUTIC AREA

Infectious diseases

USE

Cefsulodin sodium salt hydrate is a third generation β lactam antibiotic and member of the cephems subgroub of antibiotics. The compound displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) crosslinking of peptidoglycan resulting in inhibition of the final transpeptidation step. Through the inability for Cefsulodin sodium salt hydrate to inhibit cefsulodin-resistant mutants of Pseudomonas aeruginosa PAO4089 growth displayed that Cefsulodin sodium salt hydrate may compete with PBP3 in addtion to PBP1A and PBP1B.

Merck Index

N/A

MDL NUMBER

MFCD07793338

CHEMACX

X1026792-4

PubChecm ID

656644

INCHI

InChI=1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

SMILES

C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)S(=O)(=O)[O-])C(=O)[O-])C[N+]4=CC=C(C=C4)C(=O)N.[Na+]

RTECS

UU1785000

Handling

Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation.

msds 1

C-1457, Cefsulodin Sodium Salt, SDS, diamond format.pdf

Certificate of Analysis 1

C-1457, K1034N.pdf

Certificate of Analysis 2

C-1457, J1142E.pdf

Certificate of Analysis 3

C-1457, J1142D.pdf

Reviews

Safety

GHS PICTOGRAMS
Handling	Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation.

Citations

Citations	Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung
	Evaluation of PCR-based methods for the identification of enteroaggregative hemorrhagic Escherichia coli in sprouts
	Comparison of the Diatheva STEC FLUO with BAX System Kits for Detection of O157:H7 and Non-O157 Shiga Toxin-Producing Escherichia coli (STEC) in Ground Beef and Bean Sprout Samples Using Different Enrichment Protocols
	Advances in methods to detect, isolate and quantify foodborne pathogens
	Within-Host Fine-Scale Evolutionary Dynamics of Infectious Bacterial Populations

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