Collagenase, Type 1

SKU
C-2823
  • CAS:9001-12-1
  • Formula:C60H100N2
  • MW:849.474 Da
  • Appearance:White to dark-brown powder

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Product Name Qty
Collagenase, Type 1
1 g
$242.81
Collagenase, Type 1
5 gm
$1,050.44

Description

Collagenases are enzymes responsible for the degradation and turnover of collagen. This is accomplished via the hydrolysis of peptide bonds in collagen that can not be broken down by other enzymes.

Type 1 Collagenase (isolated from Clostridium histolyticum) includes a balance of collagenase, caseinase, tryptic and clostripain activity. It is recommended for isolation of liver, lung, epithelial and adrenal primary cells in the laboratory.

Applications

One common research application of collagenase is the isolation of primary cells from tissue samples. Other research, however, has focused specifically on collagenase and its physiological roles. Excessive collagen turnover by collagenases has been studied as a cause of joint diseases. Collagenase has also been studied as an actor in the wound repair process.

 

More Information
Alternate Name/Synonyms
Clostridiopeptidase A; Collagenase from Clostridium histolyticum
SKU
C-2823
CAS #
9001-12-1
Chemical Name
(5S,6S,9R,10S,13S,17S,23S,24S,27R,28S,31S,35S)-5,6,9,13,17,23,24,27,31,35-decamethyl-10,28-dioctyl-2,20-diazanonacyclo[19.15.0.03,19.05,17.06,14.09,13.023,35.024,32.027,31]hexatriaconta-1(21),2,19-triene
Chemical Formula
C60H100N2
Molecular Weight
849.474 Da
Appearance
White to dark-brown powder
Solubility
Clear colorless solution
Storage Temp
+4°C, desiccated
THERAPEUTIC AREA
Not Applicable
USE
Collagenase is a protease that cleaves the bond between a neutral amino acid (X) and glycine in the sequence Pro-X-Gly-Pro, which is found with high frequency in collagen. Collagenase is unique among proteases in its ability to degrade the triple-helical native collagen fibrils commonly found in connective tissues such as skin, tendon, blood vessels, and bone. Collagenase disaggregation is suitable for the culture of human tumors, mouse kidney, human adult and fetal brain, and many other tissues including epithelium. Collagenase is relatively gentle, dissociates well at physiological temperature and pH, and requires no mechanical agitation or special equipment.
Handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
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