Cytochalasin B is a heterotricyclic compound that acts as a mycotoxin. Cytochalasin B inhibits cytokinesis during cell division by preventing microfilament formation. While preventing cytokinesis from occurring, this compound exerts no effect on the division of the nucleus. Cytochalasin B also inhibits several processes within cells, including both the formation of actin filaments and the normal transport of glucose. Cytochalasin B acts as a microtubule inhibitor isolated from Helminthosporium dematioideum.
Owing to its ability to permeate cells and inhibit several aspects of their ordinary activity, cytochalasin B has been used widely in cytological research to investigate cellular processes. Along with the other cytochalasins, this compound has also been studied as a potential anticancer drug. In both in vitro and in vivo studies, cytochalasins have been shown to damage cancerous cells to a greater extent than non-cancerous cells. Another line of investigation into cytochalasin B's in vivo effects has focused on its ability to restore elasticity to the skin cells of mice by impeding f-actin polymerization. Cytochalasin B also induces cellular DNA Fragmentation.
Store in a freezer upon arrival, at -10°C to -25°C.
For laboratory and research purpose only. Cytochalasin B is often used in cytological research. It inhibits cytoplasmic division by blocking the formation of contractile microfilaments. It inhibits cell movement and induces nuclear extrusion.
Protect from moisture. Use the original container to store the product. Keep the lid tightly closed. Avoid exposing to strong direct light.
Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation
Patrick R. H. Steinmetz, Fabiola Zelada-Gonzáles, Carola Burgtorf, Joachim Wittbrodt, and Detlev Arendt
PNAS, Feb 2007; 104: 2727 - 2732.